keep an eye on ferroptosis…

[Maxone73]

ncbi.nlm.nih.gov/pmc/articl...

[PCaWarrior]

72 hours repression via SPA: Supraphysiological testosterone induces ferroptosis and activates immune pathways through nucleophagy in prostate cancer – PMC ncbi.nlm.nih.gov/pmc/articl...

[Maxone73 in reply to PCaWarrior]

So ferroptosis could be the "paradox" behind BAT mechanism?

[j-o-h-n in reply to Maxone73]

Ferroptosis = is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in human cancer. Jul 24, 2023

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/16/2023 7:20 PM DST

[PCaWarrior in reply to Maxone73]

Chances are no. It could be one of the many therapeutic mechanisms.

I think that the odds now favor DNA double strand breaks and also AR deregulation/de-mutation.

The DNA DSB aspect doesn't seem to be debated. It appears that now the question is how to optimally exploit this. Thus we see trials with radiation therapies, chemo, etoposide, and olaparib.

I've been using a pulse of olaparib with BAT for the last year. I'm about to add SBRT.

Not really a paradox. Huggins termed it hormonal interference. We have known about this for decades but we are good at forgetting.