mCRPC- What is double negative prostate cancer along with the other 4 subtypes.

[V10fanatic]

In research trying to understand my PSMA-negative FDG-positive current scenario I've come across some interesting articles that I thought I'd share with the group. I'm consulting with a new MO on Wednesday and I'm hoping she can shed some light on my progression.

This paper came out 2 weeks ago- it's a long read, but provides info on the five distinctive histologic and expression-based subtypes of mCRPC : adenocarcinoma (AR+/NE−), double-positive (AR+/NE+), low AR (ARL/NE−), neuroendocrine (AR−/NE+), and double-negative (AR−/NE−)

aacrjournals.org/cancerres/...

This U of M article talks about the role of ARSi utilization and how it leads to mCRPC in a more laymans approach.

michiganmedicine.org/health...

[Carlosbach]

interesting info. Thanks for sharing. It will be interesting to see what (if any) changes in treatment these findings will suggest to the specialists

[Gearhead]

OT: Viper owner?

[V10fanatic in reply to Gearhead]

Former. They're too wicked to drive with my compromised reflexes and spatial awareness(effin ADT). I had a '96 GTS, 2001 ACR, 2002 Bumblebee, 2005 Copperhead, 2006 First Edition, 2008 Snakeskin 'vert, and a 2013 GTS- I was bangin' gears back in the day!