is there a difference between having a germline BRCA 2 mutation vs a somatic ? My dads is somatic not inherited ? They saw this by testing the tumor. I'm still a bit confused on it all can anyone clarify. Also is olparib safe with Zytiga? Any thoughts.
brca 2: is there a difference between... - Advanced Prostate...
brca 2
Written by
Chris52981
To view profiles and participate in discussions please or .
Read more about...
2 Replies
•
Hello Chris,
Your question is very timely. Just a few days ago the FDA approved combining the PARP inhibitor Olaparib (Lynparza) with Abiraterone (Zytiga) for men with metastatic prostate cancer. Several articles about this. Good luck!
Germline means it's in his inherited genes. Somatic means its only in his tumors. They both respond to PARP inhibitors. Several recent trials have shown the value of adding Zytiga with it:
Not what you're looking for?
You may also like...
"Undetectable"
We hear the term of "undetectable" with a psa of < .1 used so often.
When I was first diagnosed...
E2 gel to fight prostate cancer.
All I ever did was to apply Oestrogel to my inner thighs, which I stopped doing years ago since my...
USPSTF Update 2024
Over 6 years later the USPSTF has yet to update the screening guidelines and we're seeing more and...
Pet scan shows stage 4
I just got diagnosis last week of prostrate cancer. My psa was 5.25. Had slight blood in pee...
Newly diagnosed Gleason 9
Hi all,
I recently had my prostate taken out and got upgraded to Gleason 9, T3b, seminal vessel...
PARP inhibitor Olaparib, phase 3 study findings (PROpel)
MRI prior to HDR Brachy and HDR intensity.
PSA holding low!!
