BRCA 2 mutation

[auroracham]

PSA now up to 16. Rising a point every two days. Went to MD Anderson. Starting a new clinical trial Sunday. We shall see what they can do. Stage 4, Zytiga stopping working after 11 months

Diagnosed July 1, 2017, PSA 104 then, Gleason 5+4, BRCA 2 mutation is the key to trial

[DeanNelson]

Praying for you, I go to MDA also same numbers on Zytiga now. Dr. Corn is my MO..

[Craigslife]

My husband is BRCA2 also. Diagnosed in 2004, gleason 9.

RP, radiation, Lupron, Provenge, Zytiga, xtandi, now olaparib. Doc is adding Keytruda next month with olaparib. What is trial?

[auroracham in reply to Craigslife]

My BRCA is pathogenic, followed my family, in fact my son has it also. The trial is avelumab in combination with talazoparib. I begin tomorrow with first infusion on Wednesday.

[Craigslife in reply to auroracham]

Thank you for your response. I am praying this combination knocks your cancer out. Please keep us informed, and I will let you know how my husband is doing on the olaparib and Keytruda.

Susan

[Tall_Allen]

Was it a somatic mutation (in the tumor) or a germline mutation (in all your cells). What is the clinical trial for - Keytruda? a PARP inhibitor? carboplatin?

[Terje in reply to Tall_Allen]

Since it follows his family and his son has it ….doesn't that imply a germline mutation?

[Tall_Allen in reply to Terje]

Probably - but they are different tests.

[auroracham]

Tall Allen, are you a doctor or a researcher?

[j-o-h-n in reply to auroracham]

And he KNOWS his stuff by golly!!!

Good Luck and Good Health.

j-o-h-n Sunday 07/29/2018 1:00 PM EDT

[Tall_Allen]

Neither - just a patient advocate.

[cbgjr]

I also have the BRCA2 gene alteration, as determined by Strata Oncology.

They listed three trials that are in progress now : rucaparib, MK-1775 and olaparib, so two are PARP inhibitors

[auroracham in reply to cbgjr]

One of my trial drugs is a PARP inhibitor and one is an immunotherapy. They take my blood today to start.

[snoraste]

I’m also BRCA2, dx’d Oct2017. Wishing you best of luck. Please keep us posted.

[Bitfiddler]

Do you know the drug in the trial or the trial number?

[grahaminator63]

My prayers are with you. I was diagnosed in July 2016, PSA 8.25 and gleason score 9. I have a germline mutation of the ATM gene. I would be interested to hear how the trial goes. Keep up the fight.