New PSMA scan

[Nusch]

SPOTLIGHT phase-3 study shows advantage of new PSMA CT Scan: auajournals.org/doi/10.1097...

[Justfor_]

"18F-rhPSMA-7.3 has lower than the average urinary excretion reported for18F-DCFPyLand68Ga-PSMA-11."

How it compares with PSMA 1007, I would be interested knowing.

[Nusch in reply to Justfor_]

Hm, I don’t know. Just found this article today on Twitter.

[RMontana]

I picked out this part of the study;

Article; "Among the 366 patients (median prostate-specific antigen 1.27 ng/mL) for whom a standard of truth (histopathology [n=69]/confirmatory imaging only [n=297]) was available, verified detection rate ranged from 51% (95% CI 46.1-56.6) to 54% (95% CI 48.8-59.3), exceeding the prespecified statistical threshold."

I think this is the same detection rate for PSMA PET, but at PSA levels of 0.50 ng/dL! The podcast I read (below) said not to wait for PSA to rise above 0.5 ng/dL and get a scan early. So unless I dont understand what this article is trying to say, I dont see a benefit here. But this study is in 'plain language,' and is technical in some ways...I may not understand. Check this out...Rick

healthunlocked.com/active-s...

[Justfor_ in reply to RMontana]

Same opinion here. Detection rate isn't better than the established radiopharmaceuticals. PSMA 1007 is better in this respect, although some silly docs badmouth it claiming the extra detections as being "false positives". In order to be able discern between more sensitive vs false detections both radiopharmaceuticals should be tested against a more sensitive one. And there isn't one to test against. It's like having two clocks and rule, by magical mind power, that one pulses faster or slower than the other. Anyone, having even the slightest experience with measurements, knows that this is an impossible ruling.

[Nusch in reply to RMontana]

Many thx. My doctor does a PSMA PET/CT regularly once a year, even while I’m on ADT.

[RMontana in reply to Nusch]

wow! Make sure you rate that doctor very high on the Internet. Typically do you have to pull teeth to get these doctors to do anything other than a digital rectal exam. what u have is fantastic because you can keep track of this monster, and make sure that it doesn’t get away. I only wish my URO had done that; it would be a completely different world for me. But we got to get the word out there and have it know that we've got to push for the scans. To heck with anything else.

This is as if someone has broken bones and you have doctors that still won’t give an x-ray to find out if there’s really a fraczture there. It doesn’t make any sense to me, but it still goes on. Great that you get a scan once a year.

PS ADT will slow the growth of cancer, but it doesn’t remove its surface antigen. If there is a tumor, the Antigen will provide the surface onto which the PSMA PET tracer will attach. So even though you’re on ADT and your PSA is low, if there’s a tumor there of any significant size, it will light up. I was told this by Dr. Calaise himself in UCLA Medical Center when I got my scan in January 20 20.

[Nusch in reply to RMontana]

Many thx for this valuable info! And let’s all push hard to get the scans we need to fight this beast.