ATM and Parp Inhibitor Lynparza

[DiverDownCA]

Has anyone had experience with Lynparza and ATM mutation?

[Tall_Allen]

Even though it's approved, it's not a good idea:

prostatecancer.news/2019/10...

[DiverDownCA in reply to Tall_Allen]

Thank you so much.He's only been on it a month and his PSA rising.

Definitely having side effects. His doctor is ordering CT scans.

I'm discussing it with the patient and encouraging him to start preparing for chemotherapy.

[Yank66]

DH was on Lynparza for about a year. He has an ATM mutation. His MO was very encouraging based on previous experience with another patient. Unfortunately, Lynparza did not work ( based on scans and rising PSA ). He had no real side effects and tolerated it better than Xtandi.

[DiverDownCA in reply to Yank66]

Thank you so much.I hope he had found a more successful therapy.

[Har036]

I hesitated to comment because I had previously reported that my husband had a BRCA2 mutation but it’s actually ATM. He’s been on Lynparza since September 2020. His last PSA was 0.04. He was treated with abiraterone prior to the Lynparza which worked only 4 months. He completed Xofigo treatment October 2021. Both treatments were suggested on his genomic findings.

[DiverDownCA]

Wow never hesitate to comment!So glad that it is working well for him!

They are all different and different combinations work differently for each of them. I think that's the hardest thing for everyone to wrap their mind around is that what works for one is not necessarily what works for the other it's not a cookie cutter ordeal.

Great news that he found something that is working for him!