Parp inhibitor

[Fight11]

Also the oncologist mentioned that he might put him on a PARP inhibitor. Any idea what that is?

[Tall_Allen]

If he has a BRCA mutation, it could increase survival. They were recently FDA-approved for it.

prostatecancer.news/2019/10...

[Fight11 in reply to Tall_Allen]

I just know he has CDK 12 gene. He had it tested Allen. I know when the report was sent over to the doctors office after it was genetically tested post prostate diagnosis. Thats what they said in in the report they suggested that he have treatment with the PARP inhibitor. Hope I’m saying that right. Sorry all new to this

[Tall_Allen in reply to Fight11]

Thare are several trials of Abemaciclib for men with the CDK12 mutation - it may be more effective than PARP inhibitors for him.

[Fight11 in reply to Tall_Allen]

Thank you so much Allen!! To be honest I’m not good at researching things!! Could you tell me a little bit about the CDK 12 gene? Or should I be afraid to ask? 😩😩

[Tall_Allen in reply to Fight11]

I'm not sure what you are asking for. Ask his oncologist about those trials.

[Fight11 in reply to Tall_Allen]

It’s a small local place!!! I think I should go a larger place such as a COE. Might know about trials and such

[Tall_Allen in reply to Fight11]

Yes, always a good idea.

[tango65]

Cancers with CDK 12 mutation may respond to Keytruda.

precisiononcologynews.com/c...

[GP24]

Olaparib has some effect with CDK12 but much less than with BRCA2/1.

thelancet.com/journals/lano...

[mrscruffy]

I have the BRCA2 genetic defect. It is a defect in one of my DNA chains. Family has been tested and a few members have it but don't have the cancer. My niece is a Pharmacist and explained it this way. My gene defect doesn't cause the cancer as mush as prevent it. The PARP inhibitor prevents the body from making a protein(I think) that the cancer needs to replicate thus "starving it to death. I am hoping to have luck with the more traditional treatments giving the medical community time to refine the PARP stuff. Interesting side note: the people at Stand Up For Cancer have a "dream team" of scientists that developed this treatment.

[j-o-h-n]

From Google:

Approximately 1 in 4 men with prostate cancer appear to have similar defects in DNA repair and can benefit from treatment with a PARP Inhibitor. The PARP Inhibitors Rubraca® (Rucaparib) and Lynparza (olaparib) have been demonstrated to delay the progression of prostate cancer in men with refractory cancer.Sep 30, 2020

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 10/17/2020 1:22 PM DST