Waiting for Pluvecto but willing to try Oxfigo

[Karirudy]

My husband Rudy and I have finished building our house in Mexico - yay! We are so, so happy. He has been on Zytiga (arberraterone?) for several months and recently his PSA has started going up from 10 to 17 to 26 yesterday. We are on the list in SoCal (San Diego) for Pluvecto but it's not available possibly for several month. The new oncologist suggested we try Oxfigo since it is specifically good for cancer in the bone. He said it may work or may not. My husband and I decided to take the consults to the scans and nuclear medicine and see about starting treatment. We hope to take a jaunt to Maui to see our new granddaughter in between treatments.

We asked if Oxfigo was easier than docetoxyl as my husband doesn't want any of that again and the oncologist said we could talk to nuclear medicine about it but it should be easier...... any input?

From beautiful Oaxaca Mexico

[Tall_Allen]

It usually has a low side effect profile, but that will depend on extent/bone marrow penetration. It may increase pain for a week or two due to inflammation from the radiation. Always use with a bone-preserving medicine (Xgeva or Zometa).

Consider combining with Provenge:

ncbi.nlm.nih.gov/pmc/articl...

My favorite local restaurant specializes in Oaxacan food and mezcals.

[Karirudy in reply to Tall_Allen]

He takes Zometra but ill ask about Provenge. We got appointments for scans next week and a consultation with NM the next day. Oaxaca de Juarez - unbelievable comida!

[mypk]

I got XOFIGO immediately after Docetaxel. In my case I had no uncomfortable side effects from the XOFIGO therapy. It kept my bone metastases stable (no change) for about 6 months, but my PSA values were rising despite XOFIGO. After that, Abirateroneacetate (Zytiga) brought my PSA values down again significantly.

[tango65]

Xofigo can't be used if there are visceral metastases. It only treats bone mets. This is the info about Xofigo by the FDA:

accessdata.fda.gov/drugsatf...

[dhccpa]

Where in Mexico? I looked into retiring there but ultimately decided against it.

[Karirudy in reply to dhccpa]

We live just outside the city Oaxaca de Juarez. 6 years now. Retired early. Love love love it.

[dhccpa in reply to Karirudy]

Interesting. I have never made it to Oaxaca. I've been in various parts of Chiapas, but I flew directly there. Maybe one day. I planned a tentative trip combining Oaxaca and Veracruz, but it never came to pass. I love Mexico, though.

[Hidden]

We lived in Oaxaca for 2 1/2 years. My husband had his first round of chemo at Clinica OSMO on Humboldt. I credit Dr Hernandez with saving his life. The RO we saw in Oaxaca recommended Xofigo when the chemo treatments were done but the only place to have them was CDMX so we decided to return to the US to continue care at VA. Unfortunately, they keep telling us he’s not ready for Xofigo though he fits all the parameters. He’s currently having chemo again, Cabazitaxal

We miss the food and our friends there!

Buena suerte with the Xofigo 🙏🏽

[MateoBeach]

Another approach you and Rudy could consider would be to do a few cycles of BAT therapy (Monthly injections of 400mg of testosterone cypionate while staying on ADT.) Very easy to do in Mexico if you can continue close monitoring of PSA during it. It can restore sensitivity to advanced androgen signaling drugs such as abiraterone and enzalutamide in some. But is NOT to be used if he has bone pain from his bone mets. Xofigo is probably the way to go. I live in San Jose del Cabo six months per year. About due for another hop over to delightful Oaxaca for a few days. Bueno suerte. Pablo

[NEHOG]

Just back from my oncology at CFCI in Boston, and I've been informed that there is no chance for any to be available until late summer!

The supplier in Europe can't supply demand. There were to be two plants in the USA to produce it however neither has been able to get FDA approval to start production, and such approval probably won't happen until this summer. I don't know why the delays.

Result is that either I'm going to be going with Radium or with a drug study. I will have to decide today as with myPSA at 375 it is getting critical. I just have to choose which route I am to follow. And as always I don't have sufficient information to make a good informed decision.

[Bethpage in reply to NEHOG]

Something might be changing with the supply because a friend's spouse received his first dose yesterday from a uro in Jupiter, FL. The uro is working with an out-of-state genitourinary oncologist who is with an NCI-designated cancer center. Another friend's husband just started Pluvicto at JH. The patient who received his first treatment in Jupiter has been on the list for just over 6 weeks. I don't know details about the JH patient, only that he just received his first treatment.

[j-o-h-n]

Drink canned coke..........................no water, tap or bottled.........Viva Mexico....

j-o-h-n <===<<< Senior management is about to spike my spikes....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 04/18/2023 7:30 PM DST

[Karirudy]

I think we'll just take it a day at a time and see how well survive up there for 12 weeks if it is we weeks. my sister has a nice place in San Jose but that will mean changing VA's again and not being able to return home as often....