Imimpramine Antidepressant to arrest Tumor Growth

[spolyu]

I heard that by taking the anti-depressiant Imimpramine that it can inhibit cancer, tumor growth. has anybody heard about this information??

Thank you

[Magnus1964]

Here is an NIH article on imipramine:

Lim EY, Park J, Kim YT, Kim MJ. Imipramine Inhibits Migration and Invasion in Metastatic Castration-Resistant Prostate Cancer PC-3 Cells via AKT-Mediated NF-κB Signaling Pathway. Molecules. 2020 Oct 11;25(20):4619. doi: 10.3390/molecules25204619. PMID: 33050597; PMCID: PMC7587212.

[spolyu in reply to Magnus1964]

Thank you

[Blackholes]

Cancer cells produce thousands of exosomes. These are virus sized chemical messengers that are immunosuppressant amongst other deleterious attributes and are resistant to current treatments. In prostate cancer it has been shown that the vast majority of PDL1 is expressed by these exosomes instead of the cancer cells themselves. Researchers at UCSF have shown that prostate cancer cells that are unable to produce exosomes can act as a vaccine and that once the immune system recognises them it can also attack PDL1 expressing cells.

Imipramine is a potent inhibitor of exosome biogenesis. In fact, it has been used in combination with PDL1 checkpoint inhibitors in a pre clinical model of Glioblastoma with some very encouraging results.

[spolyu in reply to Blackholes]

Thank you very much

[Scout4answers in reply to Blackholes]

Great info are you taking Imipramine?

[Scout4answers]

Great find! are you taking this?

[spolyu]

I just found out about this. I will discuss with MO. Thank you