I've been struggling to maintain my mental health since my last elligard injection. Details in my reply to No_stone_unturned's post on "Does mind over matter work?"
SandyBear 2023 posted "Do you also have these symptoms?" These two posts, along with my own recent experience led me to do a quick search on the literature on lueprolide induced psychosis. I don't have access to any academic search engines, but my search on Google returned several results. Many of these are rehashings of the same cases, but still there is some literature to support the validity of our SE's. Unlike many of you, I don't claim to be able to establish the validity of the studies, but I though many of you might be interested.
Excerpt One (core.ac.uk/download/pdf/826...
"2. Case report
We describe the case of a 62-year-old man without previous psychiatric history or mood disorder diagnosed in October 2010 with prostate cancer, which metastasized to the bone. Androgen deprivation therapy was administered monthly in the form of leuprolide acetate (3.75 mg) subcutaneous injections. After the second dosage, the patient gradually became increasingly elated, expressive, hyperactive, and increasingly talkative about his work and future plans. A decreased need for sleep also developed.
The patient’s medical history revealed no drug abuse or alcohol consumption until that time. Laboratory examinations showed normal thyroid and adrenal function. A toxicology screen was negative for illegal substances. However, impaired liver function was revealed, and may have been caused by hepatitis C. Brain magnetic resonance imaging demonstrated atrophy, but no obvious brain or skull metastases. Electroencephalography revealed no overt abnormalities; however, hypersomnolent tendencies were noted.
Upon admission, oral neuroleptic drug treatment was started (risperidone and haloperidol) under the diagnosis of substance-induced acute manic episode, according to the criteria of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders. Manic symptoms subsided 1 week after administration of this treatment. One month after discharge, the patient’s overall good condition allowed discontinuation of leuprolide acetate. Follow-up revealed no psychiatric symptoms requiring hospitalization. Risperidone for controlling symptoms was also discontinued."
Excerpt Two
"Case report.
Mr A, a 65-year-old white man, was brought into the emergency department by the police after they were called by his wife. She reported that he was extremely agitated, shouting profanities, threatening her, and accusing her of being schizophrenic. Over the last 3 to 4 weeks, he had been progressively sleeping less, only sleeping 1 to 2 hours per night immediately prior to admission. He had persecutory delusions regarding the Mafia and FBI. He was hyperverbal, had pressured speech, and was repeatedly quoting the Bible. Over the past several weeks, he had been displaying bizarre behavior, such as impulsively buying objects he had no use for and excessively spending money. He had also been irritable with his wife and using profanity, which was unusual behavior for him. At the time of admission, an accurate history could not be obtained from the patient, and therefore the majority of the information was obtained from his spouse.
Laboratory test results on admission, including thyroid panel, basic metabolic panel, complete blood count, and urinalysis, were all within normal limits, except the patient’s red blood cell count (RBC) was 3.88 M/mm3 (normal: 4.00-5.30 M/mm3) and his hematocrit was 35.5% (normal: 38.0%-46.0%). The rapid plasma reagin test result was negative. A toxicology screen was negative for illegal substances. The patient’s blood alcohol level was undetectable, and neurologic examination results were unremarkable.
When Mr A arrived in the emergency department, he was agitated and combative. He struck a nurse and threatened to hurt other staff members. At this time, the patient had to be placed in 4-point restraints. He also received haloperidol 5 mg intramuscularly. He was then involuntarily committed to the psychiatric inpatient unit.
The patient’s past medical history was significant for prostate cancer, and he had received radiation seed implants 4 years before. However, 3 months prior to this admission, his prostate-specific antigen levels became elevated. Upon the recommendation of his physician, the patient received leuprolide 45 mg subcutaneously approximately 2 months prior to this admission; this dose is intended to be administered once every 6 months. His past medical history was otherwise unremarkable. The patient had no history of psychiatric illness. His wife reported that his current behavior was an extreme deviation from his normal behavior. She reported no other recent medication changes. There was no evidence of metastasis."
I would welcome any input, insight, advice, etc. from you, my experienced colleagues.
bone scan following chemo
Father Has Aggressive Prostate Cancer
So who should I be angry with-
Zytiga
