Metformin effect on Testosterone

[ron_bucher]

Anyone have a significant drop in T after starting Metformin?

[petercraig2]

No no me although I'm taking 1500/day.

My Testosterone and PSA both dropped below measurable levels and attributed to impact of Estrogen patches.

All seems to be good and stable with minimal adverse impacts.

[Hidden in reply to petercraig2]

Were you given a prescription for the estrogen patches? What strength and type estrogen patch? Thank you!

[petercraig2 in reply to Hidden]

Yes I provided several clinical documents on use of Estrogen patches to my Clinical Oncologist, we discussed and he wrote the prescription. Metformin was prescribed simply because men using it for Diabetes had been shown to have a longer survival.

I started with 4x 100mg patches and changed two everyday, then when PSA had dropped to <.008 went to 4x 75mg patches changing two everyday with confidence in stable PSA reduced to 2x75mg + 2x50mg changing one of each every day. Again when we had confidence again reduced to 2x100mg patches and changing one every day. There was a very slight uptick in PSA from <.008 to .01 and so with fine tuning am on x3 100mg patches changing one each day.

Seems to work extremely well with a rotation of patches the Estradiol level seems to be very stable. In theory patches are supposed to be good good for a week but not my experience. My Oncologist is very impressed and has in fact put several other patients on same therapy due to cardiac issues.

No sweats, no cardiac arrhythmia just man boobs that I can live with as Estrogen patches has the cancer in a choke hold.

My biggest challenge was finding a sympathetic Clinical Oncologist who was willing to listen and discuss which is rare. Had to get away from my Surgeon and Radiation Onc. simply because they pretend to know everything but most don't know anything apart from SOP

Hope this is useful

[Hidden in reply to petercraig2]

Peter, thank you for your thoughtful reply regarding the patches. Jim also believes in the use of metformin.

[timotur]

Ron, pretty sure the muscle injury is related to low T as it causes loss of muscle mass and strength. You probably compensated for this by swinging harder and tore a muscle. Had something similar while on ADT with T < 12 ng/ml, tore my superspinatus muscle playing tennis, and it never fully recovered.