Access to Kwon article

[NickJoy]

Does anybody have access to this article? Or know how I can get hold of it without the big payment?

Addressing the need for more therapeutic options in neuroendocrine prostate cancer.

pubmed.ncbi.nlm.nih.gov/366...

Thank you

[dockam]

I was able to cut this, was there more to it?;

Neuroendocrine Prostate Cancer (NEPC) is a rare form of prostate cancer. People with NEPC have typically had previous treatment for prostate cancer. NEPC is typically found after prostate cancer cells have spread outside of the prostate. NEPC may not produce typical prostate cancer markers such as Prostate Specific Antigen (PSA). This can make detection of NEPC difficult. NEPC is difficult to treat because NEPC does not respond very well to typical prostate cancer medications. Because of this, people with NEPC typically have a shortened survival. Many researchers have been developing new ways to find and treat NEPC. New methods of imaging with PET/CT scans are better at detecting NEPC than standard imaging. Treatments that specifically target NEPC cells are currently being researched, but these treatments have not been used on any patients yet. This article describes these research efforts and recommends that more research should be done to find treatments for NEPC.

[dockam]

Oh and this: Introduction

Neuroendocrine Prostate Cancer (NEPC) is an aggressive form of prostate cancer frequently seen after prolonged treatment of Castration Resistant Prostate Cancer (CRPC). NEPC has become increasingly prevalent over the last 20 years, with a poor prognosis caused by a late diagnosis and limited treatment options. Recent advances in PET/CT imaging and targeted radioimmunotherapy are promising, but more research into additional treatment options is needed.

Areas covered

The aim of this review is to analyze the current imaging and treatment options for NEPC, and to highlight future potential treatment strategies. A Pubmed search for “Neuroendocrine Prostate Cancer” was performed and relevant articles were reviewed.

Expert opinion

The recent FDA approval and success of 177 PSMA Lutetium in CRPC is promising, as 177 Lutetium could potentially be paired with a NEPC specific biomarker for targeted therapy. Recent laboratory studies pairing DLL3, which is overexpressed in NEPC, with 177 Lutetium and new PET agents have showed good efficacy in identifying and treating NEPC. The success of future development of NEPC therapies may depend on the availability of 177 Lutetium, as current supplies are limited. Further research into additional imaging and treatment options for NEPC is warranted.

[NickJoy in reply to dockam]

Thank you. I thought there would be a long article but looks like I read it wrong and that was all there was.

[NotDFL]

One can contact the authors (Mayo clinic) and ask them for a 'reprint', citing your interest as a patient.

However, they do not delineate a specific therapy; specifically, I cite:

Treatments that specifically target NEPC cells are currently being researched, but these treatments have not been used on any patients yet. This article describes these research efforts and recommends that more research should be done to find treatments for NEPC.

[NickJoy in reply to NotDFL]

thank you

[BerkshireBear]

There is a method to reach such articles in this post to this forum:

healthunlocked.com/advanced...

I believe this used to be in the list of Pinned Posts. It probably should be returned to that status.

[NickJoy in reply to BerkshireBear]

thank you

[Concerned-wife in reply to BerkshireBear]

it is stilled under Pinned posts

[tn12]

Hi NickJoy, we're you diagnosed with NEPC?

[NickJoy]

My husband had a large amount of NEPC cells in prostate in biopsy.