Hello folks! I checked my blood results today (and I have an appointment next week with the oncologist to discuss them.) Basically, I had an RP in the summer of 2019 with a Gleason of 4 + 3. I had follow-up radiation and hormone therapy for 9 months. Both testosterone and PSA went to and stayed undetectable. I then stopped all treatments. In January 2021, testosterone gradually recovered to mid-range normal levels and PSA was initially undetectable and then later very tiny with a very slow rising trend. In the last 9 months or so, the testosterone has gradually been going down (it's still within normal, though), while the PSA has been gradually rising (currently less than 0.1). I know what rising PSA generally means, but coupled with the decline in testosterone? Does it mean I'm becoming hormone-independent? Castrate resistant? What do you think? What options? I'd like to have some of your valuable information and opinions going into next week's appointment. Please and thank you.
Testosterone gradually going down whi... - Advanced Prostate...
Testosterone gradually going down while PSA gradually going up (I'm not currently on any treatment)
Castration resistance is only when testosterone is at castrate level (<50 ng/dl), not when it is normal.
Thank you Allen for clarifying that.
What about estradiol levels ? How do they relate to PSA and T levels ? Would a rise in PSA combined with a drop in testosterone automatically cause/ indicate a rise in estradiol ?
Natural estradiol levels increase when testosterone increases. It is a metabolite of testosterone.
My last BT shows PSA 0.019, T 9.78 ( range 6.68-25.7 ), estradiol 201 ( range 41.4-159 ). This was the first time I tested for estradiol. Testosterone actually dropped from 11.40. Should I be looking for something there ?
Estradiol goes up with androgen receptor blocker monotherapy (e.g., Casodex) because the testosterone has nowhere to go and accumulates, causing excess estrogen. That's why it caused gynecomastia.
IDK why your E2 increased.
Thank you for your answers.
Testosterone fluctuates a lot. If it’s still in normal range it probably means nothing. Try to get tested at roughly the same time of day each visit.
Has anyone seen testosterone rise on xtandi while still on lupron?
PSA going down?
testosterone finally moving up after Treatment.
PSA Still Going Up
After BCR and PSA Return: An Update on My Treatment Path
