Is it too late for Triplet Therapy? (4 months on Elligard already.).

[Gl448]

Switching to Dr. Dorff from old MO. First appointment on 12/28.

Hoping to get Triplet Therapy that old MO basically said no to. That MO also dragged out any treatment beyond initial Elligard injection for two months waiting for a bone biopsy that she ultimately ignored the results of.

Anyways, diagnosed 08/11/2022 and received 6 month Elligard injection 08/18/2022, so 4 months now on just Elligard.

Some other posts here sounded like Triplet needed to start within 2 months of ADT. Is that really an issue? Obviously Dorff will know best, but wondering what to expect, so I don’t get surprised.

PSA is about 2 last month, down from a single one time high of 9 (which was right after TURP and Foley catheter trauma.). PSA was always 1 or less in the past.

Also, old MO took 3 weeks to get the Xtandi Rx she wanted me to start processed. Pharmacy just called and left message about shipping instructions.

With seeing Dorff in just 9 days, I’m thinking I should hold off on getting/starting the Xtandi because at this point, what’s the point if NUBEQA is coming?

Any thoughts appreciated.

[Tall_Allen]

I agree - see what Dorff says next week.

[Zengal79]

I would be inclined to wait as well. We traveled across the country to see her and she was impressive. Best wishes to you in your journey. You’re in good hands.

[hopefull99]

Seasid

You have a wonderful story. I am particularly impressed that you were able to chart your own course and had cooperating doctors.

I also have a question ... do you have any strict diet and supplements regimen?

[Seasid in reply to hopefull99]

I eat everything what I want. I don't have any restrictions in my diet i only started vitamin d3 and vitamin B12 as I am low on them.

[Mrtroxely]

HiI read your bio.

That is similar situation as found myself in....

Regards catheta, turps, scrapes, things getting jammed down my thingymijig.....

I was sat waiting in my surgical socks and the doctor came in telling me he was removing bits of my prostate and and I'd have cathiter for 2 weeks and need be resting 2 weeks....

This was being told it was a little scrape and be few days recovery....

My blood clots at time were horrific!

This was being done through hospital...

I didn't feel it was right, so I didn't go through....

Shortly after the doctor said I'd mad a good decision and gave me bicultumide tablets and reffered me oncologist!!!!

4 days into the bicultumide

The clouds lifted, the sun burned through the sky, the heavens sung with angers and I stopped urinating claret blood and clots that looked like the world map every time I urited...

And sometimes unable to....

I hope things work out for you....

That's gotta be one of lowest points leading up to that bicultumide in my life....

I'd researched more on taking my own life than looking at anything else at times....tough times

[Mrtroxely]

I'm I chemo 4 of 6 and asked to not have predisolone with doxetaxel Chemist said it's ok as new research has said it doesn't have benifit for cancer...

But just covers appitite and energy....

There's a few in my cupboard if I really want them!!!

But still take dexamethasone steriod 8 a day before and 4 before chem in.

I'm writing this 'wired' not much sleep ather I just had the chem and those dexamethasone steriod tablets(apperently the stop bad reaction when getting chemo??? Did you have them...

[AlvinSD in reply to Mrtroxely]

I only got dexamethasone…start the day before (AM and PM dosing), day of chemo (AM and PM) and one dose the morning after chemo. ( They told me they only give prednisone for CRPC patients.)

[Gl448 in reply to Mrtroxely]

Seasid, Y’all have totally hijacked my question and I’m getting notifications about topics I’m not currently worried about. I asked about timing of triplet therapy and you’ve turned this into a totally different topic focused on your chemo experience. Can we stay on topic or start a new thread?

[Mrtroxely in reply to Gl448]

Hah!Sorry dude.

Chemo/dexamethasone steriod brain....

Personally triplet therapy with the chemo/ADT/arbitorone after all the reading I've done sounds like

Hit hard and fast, it looks like a curitive action(not a palutive decision)

UK don't offer this.....

The xandi you've said needs 2 weeks to leave the body and flush out and may cause delay.

If had choice I'd push for it, hit hard n fast and all in one....my treatment was

ADT and chemo (that's UK version of hard n fast....)

But sounds like you have other cancer related issues that your new oncologist would really help you make the best informed decision.

Hope you ok and the thread not to diluted.

Hope the best thing for you happens.

[Mrtroxely]

Yep, ill learn be bit more on topic.No probs

[MateoBeach]

cycling back to your question. I would wait for Dorff visit. You will likely feel much better on Darolutamide than Xtandi. But to get it approved as triplet therapy you need to get started with docetaxel chemo promptly as well. 6 cycles, steroids optional, and stop at any sign of neuropathy.

[Gl448 in reply to MateoBeach]

Thank you for circling back on topic. This thread turned into a very wordy beast that’s barely related to the very specific question I asked.

Side effects of Xtandi vs darolutimide was the final straw in losing confidence in my current MO. She told me they’re not bad and then gave me a two page handout describing how bad they are.