arib1 mutation

[Purplehayz]

Have any of you had a treatment that was successful against arib1 mutation. PSA is slowly but steadily rising and PSMA so increase in dize if mets.

Thanks

[Tall_Allen]

Do you mean RB1?

A small trial suggested that BAT may be useful in men who had RB1 and tp53 loss (but not rb1+pten loss), and these men responded to the combination of Jevtana+cabazitaxel:

ncbi.nlm.nih.gov/pmc/articl...

ncbi.nlm.nih.gov/pmc/articl...

If its neighbor gene, SUCLA2 is also deleted (as sometimes occurs), a lab study suggests thymoquinone (2-isopropyl-5-methylbenzo-1,4-quinone) and PMA (phorbol-12-myristate-13-acetate) may be able to target it. Hopefully, this finding may someday result in a clinical study.

nature.com/articles/s41388-...

[Purplehayz in reply to Tall_Allen]

When the MO said it, it sounded like what I typed above, but be’s goven us no paperwork that states anything about this tumor mutation. It’s been like pulling teeth to get any documents ffom this team if doctors. Thanks for replying. I will look at the link you posted.

[tango65]

Are you referring to gene ARID 1?

medlineplus.gov/genetics/ge...

[Purplehayz in reply to tango65]

Possibly? We recorded the appointment and it sounded like a “b” but maybe this is what he meant?

[Purplehayz in reply to tango65]

Thanks, this sounds like it may be what the MO was talking about. I appreciate the link.

[tango65 in reply to Purplehayz]

Best of luck.