Trying to understand if I got a good or bad news...
Anyone with ATM gene mutation? - Advanced Prostate...
Anyone with ATM gene mutation?
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Yeah...ATM here...how was it found? Germline, Tissue Biopsies or Liquid Biopsy?
Germline (venous blood)
If you have kids, make sure they get a germline test too... anyway, you'll mostly be interested in the ATR Inhibitor trials and PARP Inhibitor as a possibility, Lynparza the primary one.
I think the platinum based chemo work better.
It's not as bad as brca1/2.
my MO presented me only the good part, like "it does not influence time to castration resistance and in case we have an extra weapon (PARPi)", but I did not like it...no kids, but a brother and two sisters (and a 95 years old mother that is a force of nature who does not need to know!!)
I think I have license to say this, my wife is 100% Italian. Lovely people that evolve into complete lunatics as they grow older.
I am a lunatic now!!
It is bad in that it is one of several possible homologous recombination repair genes (HRR), which means that mistakes in your DNA are not corrected. This increases your propensity to get any kind of cancer. However, unlike BRCA mutations, it does not respond well to PARP inhibitors. Olaparib is FDA-approved for it in the US, although it is ineffective for it. There are no specific medicines for it, although men with it respond to hormone therapy and taxane chemotherapy.
There are a couple of early clinical trials targeting it:
clinicaltrials.gov/study/NC...
clinicaltrials.gov/study/NC...
Thanks TA. Very interesting. Are you aware of any research being done with early-stage PCa patients (I am an Active Surveillance Gleason 6 member of the club). I have the ATM gene mutation, otherwise completely healthy at age 54 (diagnosed at age 51). I would raise my hand to participate in such trials if they are being planned/considered...
Yes, thank you TA. I have ATM gene mutation and was told it is common and not to worry about it.
i have it. dx'd at 49. 5.5+ years on abi/pred/lupron and radiation to two mets. recently radiated prostate and dropped the abi/pred.
urotoday.com/video-lectures...
"We also, of note, saw high rates of responses in those with ATM mutations, CDK12 mutations, and other genes that didn't necessarily show high response rates in some of the other studies testing rucaparib, olaparib, and some of the other prostate cancer PARP inhibitors that are being developed."
clinicaltrials.gov/study/NC...
I noticed, but I have found also something elese very interesting (not PCa related but ATM related):
actionforat.org/crispr/ but I need to discover more
link.springer.com/article/1...
it's a field where I have some secondo degree connection with a couple of biotech startups. By the end of the year some CRISPR treatments were supposed to get FDA approved and start commercialization...