These Results are from the biopsy samples from when my husband was diagnosed this past July 2022,
PSA 942.40, Gleason 8, Ductal w/ crib from architecture,
4 cores out of 15, 44% Ductal PCA average from 4 cores, more info in bio
3 Lytic Lesions, Pelvic Lymph Node Involvement, Thoracic Lymph Node ,
Please look at percentages, Tall_Allen What do you think?
I don't know why you think percentages help?
Are the percentages out of a 100% do you know?
There are gene mutations that are cancer bio markers and it’s sadly distressing….the other reason we are looking as the other issue is the sever plaque psoriasis and the inhibitor my husband must use, either a pde4 like Otelza, which certain research shows pde4 drives, TP53, HRAS, WT1…and possibly using a biologic like a IL-23.
I would think a IL-17 would be out of question…but they are all TNF
Suppressants
I think Shooter said that we need at least a percentage of 30 % of the actionable mutations in order to be useful. Can you contact shooter? I am just a Postman. Shooter said that ones. And It made sense to me. Maybe I misunderstood something.
Thank you, I will give it a try
Seasid I got the percentages, so what do you think?
What is the percentage?
As so often is found, there is nothing currently useful there, unfortunately.
Isn’t that something after decades of research,
The most important thing, the cell, nucleus and the reception of therapies that are needed to beat cancer, and gene mutations must be dealt with to modified these therapies so they work in and with the individual’s DNA
There is a mutation in the TP53 gene which usually favors cell replication. PC with this mutation may respond to BAT (Bipolar androgen therapy).
ncbi.nlm.nih.gov/pmc/articl...
BAT is experimental but there are clinical trials
clinicaltrials.gov/ct2/resu...
and most oncologists know the protocol and they could use this treatment.
Well, we asked my husband’s MO at a major Research Teaching Hospital in NYC and he said it doesn’t work….we don’t know what to think about his comment
That is correct for a general population of patients but it may work in selected patients depending on the mutations of the cancer. Cancers with PT53 mutations may respond to BAT therapy.
Thank you
Bleeding after salvage radiation 
BCR but Neg PSMA scan, ? appropriate next step
Locally advanced/stage
History of my cancer becoming castrate resistant
