Post-diagnostic low-dose zinc supplement use among nonmetastatic associated with lower risk of lethal PCa and all-cause mortality.

[Graham49]

Post-diagnostic Zinc Supplement Use and Prostate Cancer Survival Among Men With Nonmetastatic Prostate CancerYiwen Zhang, Konrad H Stopsack, Kana Wu, Mingyang Song, Lorelei A Mucci, Edward Giovannucci

The Journal of Urology, 10.1097/JU. 0000000000003080, 2022

Purpose:

Biological and experimental evidence support restoration of normal zinc levels in malignant prostate cells as a promising prostate cancer treatment, yet the influence of zinc supplementation after diagnosis on prostate cancer survival in a human population is unknown.

Materials and Methods:

We prospectively assessed post-diagnostic zinc supplementation in relation to prostate cancer survival among 5,788 men with nonmetastatic prostate cancer in the Health Professionals Follow-up Study (1986-2019). We used Cox regression models to estimate the multivariable hazard ratios and 95% confidence intervals of lethal prostate cancer (distant metastases or prostate cancer–specific death) and all-cause mortality according to post-diagnostic zinc supplement use and dosage.

Results:

During a median follow-up of 11 years, we documented 527 lethal prostate cancer events and 3,198 all-cause deaths. Fifteen percent of men reported zinc supplement use post-diagnosis. Compared to nonusers, post-diagnostic zinc supplement use was associated suggestively with a lower risk of lethal prostate cancer (HR [95% CI], 0.82 [0.60-1.13]) and significantly with all-cause mortality (0.84 [0.74-0.96]). The inverse association was mostly observed among men who used post-diagnostic zinc supplements of 1-24 mg/d (lethal prostate cancer: 0.55 [0.32-0.96]; all-cause mortality: 0.77 [0.64-0.93]), while higher dosage did not show a lower risk.

Conclusions:

Post-diagnostic low-dose zinc supplement use among nonmetastatic prostate cancer patients was associated with lower risk of lethal prostate cancer and all-cause mortality. A potential benefit of low-dose post-diagnostic zinc supplement for prostate cancer survival merits further study.

[Nusch]

I‘m supplementing Zinc, too. Thx for your post! Main reason, why I decided for Zinc supplementation: You can monitor your daily intake with apps such as Cronometer. It gives you all the details. So I learned, that I‘m short on Zinc, Iodine and Calcium, based on my whole food plant based diet. I started supplementing these three couple of months ago and feel much better and stronger now. Also got faster on my daily runs.

[Jalbom49]

great that you are supplementing zink. But you can develop copper deficiency.

Best is a supplement that contains copper and zink. I get zink from red meat but when I feel the beginnings of a sore throat I use zink lozenges with great results.