Trial in Troy Michigan,

[lewicki]

The LU-177 trial.

Is there any trial activity for AC-225 in Michigan?

Thanks

[tango65]

List of prostate cancer trials in Michigan

clinicaltrials.gov/ct2/resu...

[lewicki in reply to tango65]

93 trials.. Amazing.

Thanks

[tango65 in reply to lewicki]

Best of luck, I hope you could find a clinical trial.

[MateoBeach]

There is one trial of Ac225-J591 recruiting at Weill-Cornell Phase 1 dose escalation so no placebo and open label. I would go for that if I met the criteria. (I don’t 🤷🏼‍♂️) very good opportunity for appropriate patients.

[gsun in reply to MateoBeach]

Has there been any progress on saving the saliva glands? I know it is being worked on here but haven't heard of any results if there are any.

[lokibear0803 in reply to gsun]

I recently came across this interview with Philip Kantoff

urotoday.com/video-lectures...

Here is some of what was said that I found most interesting:

…given that it's an antibody, interestingly, antibodies that are directed at PSMA don't bind to the salivary glands or lacrimal glands, so they don't cause the same xerostomia, dry mouth, dry eyes, that ligands do.

…The main side effect that we see with antibody alpha particle is hematopoietic toxicity. And the reason for that is … a bystander effect…And the patients that have been put on the study so far have very far advanced disease with very infiltrated bone marrow. So when you give an alpha particle to these patients, it goes to where the cancer is because it's targeted with the antibody. And as a bystander are the hematopoietic stem cells or the precursors that are affected. So you see transient thrombocytopenia.

…alpha particles are better at treating smaller volume disease than treating larger volume disease. Beta particles are probably better at larger volume disease than alpha particles. So that speaks to the synergy between the two and to moving it earlier in disease when people have small volume microscopic or small volume metastatic disease. We'd like to get to early disease where we could potentially cure patients with say PSMA positive disease, traditional scanning negative disease, and we have a chance at eradicating disease at that stage.

…I think that there is the possibility of taking patients with biochemical recurrence who have microscopic metastatic disease and avoiding hormonal therapy for a period of time, and using alpha particle therapy, antibody therapy, or radioligand therapy early in disease systemically, and maybe using focal radiation as well for sites of disease and avoiding hormonal therapy and potentially curing patients. So studies like that are on our agenda.

HTH —

[austinsurvivor in reply to lokibear0803]

This could be a game changer for many of us with low volume metastatic mets in lymph nodes. The fact that it is antibody and not ligand binding means no salivary gland destruction. I'd sign up for this today is I wasn't adt sensitive currently.

[lokibear0803 in reply to austinsurvivor]

Yeah, I know, that was exactly my thought on reading this. Mr Kantoff is flat out saying they intend to get earlier stage BCR patients into trials with the Ac225-J591 combo.

I just hope they don’t structure it to exclude folks like me who’ve already done ADT, NHT, etc. PSMAddition did that, sigh.

[lewicki in reply to gsun]

When in Germany I was not aware of the doctors there doing anything for the saliva glands. I do not think they were aware of the damage or it was an acceptable cost for the treatment results side effects.?

But my saliva glands are slowly recovering to where it is not as much as an issue. The mouth doess get dry from talking to much and I do drink a beer with dinner to help. I have been able to accept the drinking the beer. Sometimes it requires two.

[gsun in reply to lewicki]

Did you get Act or Lu?

[lewicki in reply to gsun]

I did both four trips.

[gsun in reply to lewicki]

please fill us in on the results

[lewicki in reply to gsun]

I am 26 months since My last lupron shot. Last PSA was <0.1. I only do dutasteride and finasteride. My PSA at one time was 750.

[TJGuy in reply to gsun]

I believe there has been at least two approaches towards LU-177 and the saliva glands. Using ICE applied to the face throat area. And one of our members mentioned sucking on sour candies or such to induce saliva production. I think that may have been our member who traveled to Australia recently, I might be wrong on who that actually was, but perhaps they might chim in.

[gsun in reply to TJGuy]

Lu evidently causes a temporary shut down of the salivary glands can but Act can be permanent.

[gsun]

So since your last Luporn shot, you went to Germany and haven't needed anything since? ADT I mean.

[lewicki in reply to gsun]

My last trip to Germany was in July 2020. My last monthly lupron was in October 2020

[gsun in reply to lewicki]

You don't have to answer, but I am interested in the cost of treatment.

[lewicki in reply to gsun]

About 12,000 USD plus air- fair food and logging

[gsun in reply to lewicki]

I take it that's per treatment.

[lewicki in reply to gsun]

Each treatment consisted of 4 GBq LU-177 and 4 MBq AC-225.

[gsun in reply to lewicki]

Can you share where you got treatment?

[lewicki in reply to gsun]

University of Heidelberg.

[lewicki in reply to gsun]

Correct

[TJGuy]

Nice article, of course the glitch with PSMA is not all PC patients express it. But even more importantly is that not all of our PC within our bodies express it. And as you get more advanced in PC more and more doesn't express it unfortunately.