white-button-mushroom-clinical-trial- - Advanced Prostate...
white-button-mushroom-clinical-trial-
Very early on I read papers about white button mushrooms out of Japan. I have been eating them ever since. I just roasted a bunch tonight for the week along with shitake, oyster and maitake. Also a bunch of cruciferous veggies. I eat them because I enjoy them, if there's additional benefits thats just icing on the cake.
This study using turkey tail shrooms did not show much help in dogs
ncbi.nlm.nih.gov/pmc/articl...
There's quite a few mushrooms used as supplements, Turkey Tail is one, Reishi, Lions Mane to name a few. I don't take supplements but I eat quite a few fresh as they are readily available here in the PNW. The only paper I read was on White Button. I know reishi and no doubt others are common in Chinese herbal medicines. I do add Turkey tail and reishi in powder for to bone broth or tea occasionally. I really to prefer to eat them. I sautéed some Lions Mane the other day with a Chipotle sauce and they reminded me of scallops, caramelized and all.
Looks like one needs to take PSP from the Turkey Tail as eating shrooms is not going to make much difference.
I agree, not doing it with clinical intent just enjoyment. However, I would take whole food over supplement every day of the week. Since joining the forum my views on supplements have changed quite a bit. Until I retire I don't have the time to research to my own satisfaction.
Although Asians have been eating Turkey Tail and making tea of it for many years, the fruiting bodies have very little PSP and it is generally not bioavailable. It needs to be extracted using both alcohol and hot water. I believe that Oriveda from Modern Herb shop are good. They are one of a very few that do third party analysis. The stuff sold in most health food stores is worthless. Fungi Perfecti etc are crap.
PSKs or PSPs? I have been using mushroom powders from Bulk Supplements, but I also eat whole white button mushrooms.
Lions Maine isn't really considered a good choice for PCa. It's more associated with nerve repair and brain function. Chaga, Reishi and Turkey Tail are considered better choices with cancer related issues. That being said, I would still eat Lions Main 
I think studies have strongly suggested the anti metastatic effect of PSP. There’s been a few threads about it in the past that were persuasive enough to get me to start taking it. Look at Oriveda PSP-50 Turkey Tail Extract. It’s somewhat pricey, but what isn’t anymore.
Thanks G
Looks like high quality with water extraction, have you found any reference to dosage for Human PCa? The dog study I posted has success with 100 mg/kg/day
I just ordered a golden bag on Amazon 180 count for $84, have you found it elsewhere for less?
Amazon’s price is about the same as on the Oriveda website. The dosing instructions (3 capsules/day) on the package are, I think, based on a prior Japanese study, which I cannot find. There are numerous posts here on turkey tail, including some by Patrick. I’m sure he can fill in the gaps.
Tbh, if found that taking the odd supplements in addition to your food to be quite limited with any results.I consider an overall strategy with a mixture of supplements but also selective foods to be more beneficial.
What I personally aim for is to target inflammation more than target a cancer. IMO, the two are highly correlated and by targeting inflammation, you also target the cancer. I don’t think it’s a coincidence that I have never caught COVID, or had any cold since following this and a LOT of people around me have…multiple times.
Typically, I look at the following foods in various combinations to combat inflammation:
Chaga tea.
Reishi and Turkey Tail capsules,
No dairy
Curcumin (not turmuric).
Wild caught fish (no red meat).
Cruciferous vegetables.
White mushrooms.
Garlic.
Ginger.
Fruits of bright colors (pomegranates, red grapes..)
Green Tea.
Carrot juice.
Vitamin D3 with K2
Natto (fermented soy beans)
Other fermented products like sauerkraut)
I mix in different combinations every day. I don’t eat the same thing over and over.
I would seriously consider some form of exercise about 3/4 times a week.
I also believe that you need to consider taking limited fats with these foods. There is something called the Randal effect which explains that the fat oxidation will lock out glucose and vice versa. So a quick hard and fast rule is either have something with high fats and no carbs, or something with high carbs and no fats. There are various videos on YouTube that explain this if you’re interested.
You and I are taking a similar approach to diet exercise and supplements. Inflammation is the enemy.
clinicaltrials.gov/ct2/show...
You guy are the best and years ahead of me. Thanks
Lol and thanks! I simply downloaded an RSS feed application and use the RSS feed link on clinicaltrials.gov. Super handy.
I'm using FeedDemon
You guy are the best and years ahead of me. Thanks
Looks like one needs to take PSP as eating shrooms is not going to make much difference
Are White Button mushrooms the same as Agaricus Blazei?
Agaricus blazei, Agaricus brasiliensis or Agaricus rufotegulis) is a species of mushroom, commonly known as almond mushroom, mushroom of the sun, God's mushroom, mushroom of life
ncbi.nlm.nih.gov/pmc/articl...
Prostate CSCs is believed to be origin of prostate tumor, which have the ability to self-renew and differentiate into the bulk tumor [35]. The fact that PSP pretreatment can significantly inhibit the tumorigenicity of PC-3 cells (Figure 3) not only highlights the anti-CSC effect of PSP, but also suggests that PSP may have chemopreventive effects against prostate cancer. We tested this hypothesis using a recently developed transgenic mouse model of prostate cancer (TgMAP) [17], [18]. The stepwise development of the prostate tumor (from low grade PIN to gross tumor) in the TgMAP mouse highly mimics the pathogenesis of human prostate cancer, although it may not totally reflect the complex nature of prostate carcinogenesis. Nonetheless, it allowed us to develop an optimal PSP treatment dosage and time frame. Whereas four weeks of PSP oral consumption at 200 mg/kg failed to produce any differences in PIN development, complete inhibition of prostate tumor formation was achieved after 20 weeks of oral PSP feeding at 300 mg/Kg. Meanwhile, the suppression of PIN formation by PSP further suggested that the chemopreventive effect of PSP may due to suppression of the tumor initiation at early stage. The extremely low toxicity and the highly potent anti-CSC effect of PSP warrants further evaluation of its chemopreventive effect in human clinical trials.
In summary, we have demonstrated, for the first time, that PSP treatment not only inhibits CSC properties, but also effectively suppresses prostate tumor formation. Our results suggest that PSP may be an effective agent for prostate cancer chemoprevention.
If you're interested in doing a deep dive into mushrooms, a great place to start in with Paul Stamets. He has a company that do excellent supplements Host Defense. Paul claimed to have used mushrooms and conventional treatments to cure his mum. I think she was stage 4. There are various videos and books you can look as references. For me, there are 3 mushrooms of interest wrt PCa - Reishi, Turkey Tail and Chaga. I've created tinctures and teas out of these three. The tinctures are a mixture of alcohol and water extractions. The alcohol extractions extracts nutrients that the water cannot. The teas are water only and I think chaga is the most palitable. Reishi is very bitter and for me, and I find it is best in a capsule form. But I do make a reishi tea every now and then. You can buy all these of course but its very expensive. You need to be careful where you purchase these from. A lot of these medicinal mushrooms come from China. So you need to do your homework to what you are buying.
My preferred mushroom, which I make a LOT, is chaga tea. I believe it can't be cultivated and has to be wild because of the extreme conditions that it thrives in. Its antioxidant ORAC value is literally off the charts. It's got the highest value there is. If you take mushrooms, you should consider the potential counteraction effects with any treatment. Remember these are EXTREMELY high in antioxidants and chemo is an oxidant. You don't want to mix the two.
You should be aware that there's also a high amount of oxalates in these mushrooms. If that is a concern to you, you could take some citrate to help eliminate it. I personally take potassium citrate now and then.
Thanks, I have several of Stamet's books and get his catalog. I have been growing Shrooms for several years but not for their cancer fighting properties. 
Its antioxidant ORAC value is literally off the charts.
I will check out Chaga mushrooms
Some people say that I'm quite dull, but I really am a fungi......
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 03/24/2022 3:08 PM DST
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