Liver Enzymes

[Rusty31]

Metastatic Prostate cancer for 10 months. On Lupron, Abiraterone and Prednisone. My Liver enzymes are starting to rise. Anyone else have this reaction and how was it handled?

[GoBucks]

Same thing happened to me in month 7. Per manufacturer, you can have AST & ALT numbers go 5 times higher than normal. So stay the course until you get close. When I got close, my MO had me stop taking Zytiga until my numbers returned to normal. That was 7 weeks. Then I started on a half dose(500mg). My ALT & AST numbers remained good and I bumped up to 750mg. Have stayed there for last 4 years all the time with PSA <0.01. Hope you have my luck.

[Rusty31 in reply to GoBucks]

Thanks Go Bucks. My MO has me off Zytiga for 10 days then blood test to see if it's the cause. I feel better about the long term prognosis.

[Tall_Allen]

Sometimes abiraterone causes liver enzymes to be elevated. Often just backing off the dose for a while (staying on prednisone) will allow the liver to accommodate. You can then raise it back up.

[Kentucky1]

Mine went up to just above normal limits. We just stayed the course and they both went back down within a few months.

[Si52]

More than 3 years ago, when I was first prescribed Zytiga, my liver enzymes numbers also went up. I was prescribed Heptral for about 6 months. The numbers returned to normal and I have stopped taking Heptral since. Hope it works for you.

[Scout4answers]

Mine rose also , now taking one 250 mil Zytiga pill in morning with 300 cal. breakfast.

See my profile for details

[Rusty31 in reply to Scout4answers]

I've only been taking one with lunch for the last 6 months. testosterone is undetectable