It is what it is but good news for my brother and nephew I think

[GreenStreet]

It is what it is but would appreciate views. I participated in a research study at RMH in the U.K. entitled “Precision Medicine in the prostate cancer care pathway: An evaluation of integrating germline genetic testing into the management at risk of/living with prostate cancer”. They tested DNA with a saliva test and found none of ATM, BAP1, BLM, BRAC1, BRAC2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2,FANCA, FANCD2, FANCI, FANCL, FANCM, MLH1, MSH2, MSH6, MUTYH, NBN, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD51C, RAD51D, RB1, SMAD4, SMARCA4, STK11, TP53, XPA and XPC. They were sequenced using the Ocogenetics “PRODICT” research panel.

This seems good news for my brother and nephew which is great and my prime concern. However it does not seem to leave me with more precise future treatment options going forwards based on current knowledge and the time taken to develop new treatment although there is loads of research in the pipeline so got to stay positive. So I was diagnosed at 56 must have been primarily lifestyle and environmental factors.

interestingly they also calculated a polygenic risk score which estimates that using my genetic information alone my risk of developing prostate cancer by age 80 at 1.34 which suggested that I am at slightly higher risk than the general population.

[Brysonal]

Great news for your family indeed. I had my germline genetic test at RMH too and like you nothing turned up. So no further on with a precision solution but like you I was more concerned for my family tbh.

I still haven’t had a somatic gene test on biopsy tissue ( I have two archive samples from pre advanced). I mat push again to get this done!

Thanks for sharing.

[GreenStreet in reply to Brysonal]

Interesting. I have not had a somatic test either. I am not sure what that would tell me since I had my RP back in September 2015. I don’t know much about this area but I expect there may have been mutations since then?

[Tall_Allen]

" must have been primarily lifestyle and environmental factors" Or just bad luck. We get used to looking for a preventable cause for every effect, but sometimes it's just random. Recent work on DNA transcription, shows that the mechanisms are surprisingly probabalistic. It's a wonder that more errors/mutations don't creep in.