Anti-Cancer Effect of Pitavastatin May Be a Drug-Specific Effect: Subgroup Analysis of the TOHO-LIP Study

[Bigm789]

ncbi.nlm.nih.gov/pmc/articl...

[Schwah]

Love to hear TA’s thoughts on people switching their statin based on this?

Schwah

[Kuanyin in reply to Schwah]

Reasons to change to Pita: (1) Zypitamag [brand name ] is processed differently by most statinsⱡ, by a process called glucuronidation. This is different from Lipitor® (atorvastatin) which is mainly processed by an enzyme called CYP3A4, part of the CYP450 family of enzymes. The CYP450 family of enzymes is responsible for 70-80% of all drug-metabolisms.1 Because of this key difference, Zypitamag has a reduce potential for interactions with foods and many commonly prescribed medications. (2) Unlike Lipitor®, Zypitamag has no interaction with grapefruit juice, and therefore, when taking Zypitamag you can continue to enjoy your grapefruit juice! (3) Increases in blood sugar levels have been seen with statin medications, including Zypitamag. In a clinical study, 4 mg pitavastatin was compared to 20 mg atorvastatin in people who had type 2 diabetes.2 In this study, there was no clinically significant difference in terms of reduction in bad cholesterol (LDL-C). However, when looking at changes in blood glucose levels of patients taking pitavastatin, there was a non-significant change in blood glucose levels compared to the patient's baseline blood glucose levels. In contrast, atorvastatin did significant increase blood glucose levels compared to baseline. If you have Type 2 Diabetes, ask your doctor if Zypitamag may be the right statin for you! (4) Unlike Lipitor®, Zypitamag has no dose restrictions or limitations when used with certain antifungals such as itraconazole. (5) Unlike Lipitor®, Zypitamag can be used together with certain antiretroviral therapies (ARTs) such as lopinavir and ritonavir.--K.

[j-o-h-n in reply to Kuanyin]

So Kuanyin.... you are worth your weight in gold....

I want to switch from Chocolate chip ice cream (two scoops) to (three scoops).....I trust you will give me some guidance (Observing the Sounds (or Cries) of the (human) World) fits you to a T.....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 07/18/2022 7:38 PM DST

[Kuanyin in reply to j-o-h-n]

Well Scoop I will now rank you "Third Degree Scoop" in accordance with my Secret knowledge of Chinese Baguazhang. I sincerely hope that you will not misuse your newly acquired powers.--K.

[j-o-h-n in reply to Kuanyin]

I promise on my ex-wife's grave (wishful thinking) I will limit my Chocolate Chip ice cream (three scoops). Thank you oh powerful one...........

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 07/19/2022 4:00 PM DST

[Medline]

Identification of foods that affect the anti-cancer activity of pitavastatin in cells

Statins inhibit the synthesis of mevalonate, a precursor isoprenoid molecule to geranylgeraniol that is necessary for the post-translational modification of several small GTPase oncogenes. Despite numerous preclinical studies suggesting that statins can be effective anticancer agents, prospective clinical trials have failed to demonstrate any clinical benefit in patients with cancer. We previously demonstrated that geranylgeraniol suppresses the activity of statins in cell culture studies, and that pitavastatin can cause regression of ovarian cancer xenografts in mice if the animals' diet is modified to avoid the inclusion of geranylgeraniol. Dietary sources of geranylgeraniol may consequently limit the activity of statins in cancer clinical trials. The present study tested several foods to identify those that affected the cytotoxic activity of pitavastatin towards ovarian cancer cells. Solvent extracts of several foods were tested for their ability to suppress the effects of pitavastatin in cell growth assays. The results revealed that pitavastatin induced cell death in ovarian cancer cells (IC50=5.2 µM) and this was blocked by geranylgeraniol whereas other products of the mevalonate pathway (coenzyme Q, dolichol or cholesterol) had no effect on the activity of pitavastatin in cell growth assays. Solvent extracts from several foods, especially oils (apart from rapeseed), also blocked the cytotoxic activity of pitavastatin. Several extracts from a range of fruit, vegetables and carbohydrate-rich foods also did not block the activity of pitavastatin. However, extracts from beans, lettuce, oats, eggs and various nuts reduced the activity of pitavastatin. These data identified foods that patients could eat to potentially improve the outcome of clinical trials of pitavastatin in cancer.

pubmed.ncbi.nlm.nih.gov/351...

[GeorgeGlass in reply to Medline]

this is good info Medline