Inflammatory, Hyperinsulinemic, and Insulin Resistant Diets and Lifestyles and the Risk of Prostate Cancer Progression and Mortality

[cigafred]

"Conclusions: Both inflammatory and insulinemic dietary and lifestyle patterns are associated with risk of PC progression." But not with risk of PC mortality.

pubmed.ncbi.nlm.nih.gov/357...

Abstract

Background: Inflammatory and insulin pathways have been linked to prostate cancer (PC); post-diagnostic behaviors activating these pathways may lead to poor outcomes. The empirical dietary inflammation pattern (EDIP), indices for hyperinsulinemia (EDIH) and insulin resistance (EDIR), and associated lifestyle indices (ELIH, ELIR) predict biomarkers of inflammation (EDIP: IL-6, TNFaR2, CRP) and insulin secretion (EDIH/ELIH: c-peptide; EDIR/ELIR: TAG:HDL) from whole foods and behaviors.

Methods: Associations of these indices with time to PC progression (primary, n=2,056) and PC-specific mortality (PCSM; secondary, n=2,447) were estimated among men diagnosed with non-metastatic PC in the CaPSURE cohort diet and lifestyle sub-study. Because the true (versus clinically-documented) date of progression is unobserved, we used parametric (Weibull) survival models to accommodate interval-censoring and estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) for PC progression per 1-standard deviation increase in index. Cox proportional hazards models were used to estimate PCSM associations.

Results: During a median (IQR) 6.4 years (IQR:1.3, 12.7), 192 progression and 73 PCSM events were observed. Inflammatory (EDIP: HR=1.27, CI: 1.17-1.37), hyperinsulinemic (EDIH: HR=1.24, CI: 1.05-1.46. ELIH: HR=1.34, CI:1.17-1.54), and insulin resistant (EDIR: HR=1.22, CI: 1.00-1.48. ELIR: HR=1.36, CI:1.12-1.64) indices were positively associated with risk of PC progression. There was no evidence of associations between the indices and PCSM.

Conclusions: Both inflammatory and insulinemic dietary and lifestyle patterns are associated with risk of PC progression.

Impact: For men with PC, consuming dietary patterns that limit chronic systemic inflammation and insulin hypersecretion may improve survivorship, especially when coupled with active lifestyle and healthy body weight.

Crystal S Langlais 1, Rebecca E Graff 1, Erin L Van Blarigan 1, Stacey A Kenfield 1, John Neuhaus 1, Fred K Tabung 2, Janet E Cowan 1, Jeanette M Broering 1, Peter Carroll 1, June M Chan 1

Affiliations

1University of California, San Francisco, San Francisco, CA, United States.

2The Ohio State University College of Medicine, Columbus, Ohio, United States.

PMID: 35767977 DOI: 10.1158/1055-9965.EPI-22-0147

[Pte82]

cigafred, do you think annatto tocotrienol has a fit as a inhibitor?

ncbi.nlm.nih.gov/pmc/articl...

[cigafred in reply to Pte82]

Sorry, do not know, I would have to research, not now.

[pjoshea13 in reply to Pte82]

As an aside, DeltaGold (annatto tocotrienol) may be a perfect match for those with PCa. The delta isoform has proven cardiovascular benefit & the gamma PCa studies suggest that it is the most useful of the eight for PCa.

The isoforms compete for uptake (which is why the SELECT study was such a bad idea - alpha tocopherol will drive down the others - including the useful gamma tocopherol & gamma tocotrienol).

I have used DeltaGold for years & no other E supplement.

swansonvitamins.com/p/swans...

-Patrick

[Pte82 in reply to pjoshea13]

pjoshea13, how much DeltaGold do you use a day?

[pjoshea13 in reply to Pte82]

Just the basic 50mg. -Patrick

[dhccpa in reply to pjoshea13]

Does Delta Gold have both gamma tocepherol AND delta and gamma tocotrienols? Thanks

[Pte82 in reply to dhccpa]

Label indicates only 90% Delta and 10% Gamma tocotrienol

[dhccpa in reply to Pte82]

Thanks yes I just saw that. Patrick had mentioned gamma tocepherol as well in his comment. I haven't found a brand with only gamma tocepherol yet.

[pjoshea13 in reply to dhccpa]

You will not find gamma tocepherol alone. 10% may seem paltry, but the delta is beneficial too. e.g. here is a paper from May:

pubmed.ncbi.nlm.nih.gov/355...

-Patrick

Apologies to Cigafred for my part in hijacking his post.

[dhccpa in reply to pjoshea13]

Thanks I saw one brand that had about 2/3 Gamma Toce. Maybe Carlson?

[pjoshea13 in reply to dhccpa]

When I was researching, there was a product with more gamma-T3, but the other stuff negated most of that IMO.

& on the basis that "heart healthy is PCa healthy", it's DeltaGold for me.

(& that's also the reason I agree with Dr. Myers promotion of the Mediterranean diet. If PCa doesn't kill us, cardiovascular disease very likely will.)

-Patrick

[dhccpa in reply to pjoshea13]

Thanks

[Pte82 in reply to dhccpa]

dhccpa, Patrick's research has served him well. I found this interview with Dr Barrie Tan offering insights to both tocopherol and tocotrienol. My good friend of many years just passed at age 86 from prostate cancer. He never let anyone know he was battling it. I saw him when I returned frozen foods stored in my freezer when his freezer failed. In that few months his face had become almost unrecognizable, I knew him by his voice. In just a few weeks he was at Hospice Care and passed there. His wife said he thought he had more time even though his doctor told him he has an agressive cancer. I'm willing to use the tocotrienol product having learned more about it now that I'm entering a time going forward when his cancer and other health issues become more likely.

wholefoodsmagazine.com/colu...

[dhccpa in reply to Pte82]

Yes, I've used tocotrienols off and on.

[cigafred in reply to pjoshea13]

Au contraire, I am benefitting, as always, from your contributions.

[Cooolone]

The all import escape clause written in such a way, that it barely gets noticed with all that scientific statistical data...

Quote from the study "patterns that limit chronic systemic inflammation and insulin hypersecretion may improve survivorship, especially when coupled with active lifestyle and healthy body weight."

The use of the word "MAY" has more weight than all the other data. It allows the reader to come to whichever conclusions they may draw from the study. As with almost every dietary proclamation, they leave the door open... Because it's almost impossible to have a study examine consumption in a controlled environment as there are too many variables.

I don't disagree with the association of inflammatory response being problematic to health even in general, let alone a cancer setting. But if find these type of studies and their publications somewhat irresponsible. It MAY means both can and cannot, you pick em' lol

[dhccpa in reply to Cooolone]

Interesting observation. I'll have to start reading RCT results (as well as other alternative studies) with an eye for that language.

[Cooolone in reply to dhccpa]

Sometimes I get too far into the weeds, but little things like this jump out at me and scream LOOK! Lol... That makes me go back and read it, again and again to try and see if I missed something. Which is a good thing. But I prefer a definitive, rather than a "may" be...

[dhccpa in reply to Cooolone]

Yep, me too

[pjoshea13]

My use of T for most of 18 years has been to reverse ADT adaptations. As such, my T target was ~1,000 ng/dL (high-normal).

Denmeade's target is ~2,000 ng/dL (twice high-normal) to induce double-strand breaks [DSB].

Perhaps one day Denmeade will have a study with two arms (1,000 & 2,000 ng/dL) to verify that DSBs are a factor in the success of BAT & to determine whether DSBs are essential.

-Patrick