Following on my Dairy-Adventist post of yesterday, here is a meta-analysis from November [1].
Some rightly asked how the Adventist study relates to advanced PCa. If dairy is associated with incidence, it might also be associated with progression. After all, dairy contains IGF-I - a growth hormone. PubMed has over a thousand hits for <prostate IGF-I>.
"We identified 34 prospective cohort studies including 3,171,186 participants and 88,545 deaths."
Men "... consuming high/whole-fat milk (fat content ≥ 3.5%)" had "increased risk of" PCa mortality "(RR:1.23 ...)"
. 2021 Nov 11;nmab135. doi: 10.1093/advances/nmab135. Online ahead of print.
Dairy Consumption and Total Cancer and Cancer-Specific Mortality: A Meta-Analysis of Prospective Cohort Studies
Shaoyue Jin 1 , Youjin Je 1
Affiliations expand
PMID: 34788365 DOI: 10.1093/advances/nmab135
Abstract
The association between dairy consumption and cancer mortality varies among studies and remains unclear. Thus, we conducted a comprehensive meta-analysis of prospective cohort studies to examine the association between dairy consumption and total cancer and cancer-specific mortality. We sought eligible studies in PubMed and Web of Science databases for all publications through March 2021, and pooled relative risks (RR) and 95% confidence intervals were calculated. We identified 34 prospective cohort studies including 3,171,186 participants and 88,545 deaths. Compared with low milk consumption, high milk consumption was associated with higher cancer mortality in females (RR:1.10; 95% CI: 1.01, 1.21) and people consuming high/whole-fat milk (fat content ≥ 3.5%) (RR:1.17; 95% CI: 1.07, 1.28). Increased risks of cancer-specific mortality were detected for liver (RR:1.13; 95% CI: 1.02, 1.26), ovarian (RR:1.32; 95% CI: 1.13, 1.55), and prostate (RR:1.23; 95% CI: 1.02, 1.48) cancers. Also, females with high consumption of fermented milk had a lower cancer mortality risk (RR:0.85; 95% CI: 0.77, 0.94). High cheese consumption was not associated with total cancer mortality, rather with higher colorectal cancer mortality (RR:1.22; 95% CI: 1.02, 1.46). There was no association between butter (RR:1.06; 95% CI: 0.70, 1.59) or total dairy product consumption (RR:0.99; 95% CI: 0.95, 1.03) and cancer mortality. Our results imply that high milk consumption, especially high/whole-fat milk, was associated with higher cancer mortality, while fermented milk consumption was associated with lower cancer mortality, and this was particularly evident in females. Consequently, further studies are warranted.
Thanks Patrick .Since diagnosis I have moved from semi skinned milk to almond milk or oat milk. I have also cut out most cheese which is a pain. Sometimes have goats cheese.
This is my favorite sentence of above. "There was no association between butter (RR:1.06; 95% CI: 0.70, 1.59) or total dairy product consumption (RR:0.99; 95% CI: 0.95, 1.03) and cancer mortality." It seems that the issue is with high fat milk. And large consumption of that. Again, everything in moderation. Will always butter my one piece of whole wheat toast (before I put my guaq on it) and occasional teaspoon of half & Half in my coffee. Thanks for posting this.
Its really is a controversial topic. Saturated fat is the most preferred fuel for Prostate cancer cells and this type of fat from animal origin is considered particularly bad.On the other hand, Milk protein esp Casein can increase Insulin like Growth factor which is not good. Small mount of dairy esp Yogurt may be fine. Yogurt is beneficial as it keeps microbiom healthy due to its probiotic activity.
Hi, LearnAll, I have also noticed that most of the studies refer to whole fat milk. Is there support for the view that fat free or low fat milk is safe? Thanks.
Animal fat is considered bad for Prostate cancer. Prostate cancer is unlike other cancers in that it feeds on fat . Other cancers feed on sugar. Its a very important difference. Milk fat is also animal fat so its consumption has to be limited in our situation. Yogurt is probably the safest dairy product for us esp if made from fat free milk.
The prefered energy source for prostate cells is palmitic acid and this continues to be the case with PCa, although cells may eventually switch to glucose.
"Palmitic acid ... is the most common saturated fatty acid found in animals, plants and microorganisms." [1]
"Excess carbohydrates in the body are converted to palmitic acid. Palmitic acid is the first fatty acid produced during fatty acid synthesis and is the precursor to longer fatty acids. As a consequence, palmitic acid is a major body component of animals. In humans, one analysis found it to make up 21–30% (molar) of human depot fat ..." [1]
You say that PCa "feeds on fat". That gives the impression that fat induces growth. The situation is that cancer cells are growing faster than normal cells, but they are controlling the rate of cell division - not the availability of fuel.
The body has a need for specific fat molecules & it manufactures these by adding to the carbon chain & creating double bonds. As you can see from the Wiki link, palmitic acid is a necessary first step.
It is futile to try to inhibit palmitic acid.
Whole milk is 3.25% fat, 1.86% being saturated . The major saturated fats are:
... palmitic = 0.857
... stearic = 0.309
... myristic = 0.303
It turns out that stearic acid is irrelevant, probably because it is easily converted to oleic acid by adding a double-bond half way - hence, omega-9.
You might find it interesting to review dr. Sarah Hallberg YouTube on dietary sat fat and carbohydrates lProstate cancer can only feed on sat fat in the blood, not the stomach.
Literature review shows studies that blood levels of sat fat goes up with increased carbohydrate consumption, not sat fat consumption as much.
This may be due to denovo lipogenesis which always produces saturated fat.
Ok, so load up on Almond (milk, powder, whatever) and get a prize like me... Oxalate Kidney Stones! Contributory as well could have been peanut butter (daily), lots of nuts, lots of dark green veggies (leaf), lots of whole grains!
Nice post. When one makes changes which work for a while and then no longer work, one tends to make farther changes, if that is what one wants to try.
It takes discipline to eliminate that which we have become accustomed to.
I imagine that there will be a day when for the right amount of money you can cure cancer. Dostarlimab, the drug developed by Glaxo that has had astonishing results curing rectal cancer. I hope it is tested with other cancers--the prostate isn't far away!
All natural milks are designed to facilitate growth of the young. As we are old, milk is inappropriate. Cheese and yogurt may be fine.As we are old, we need repair or apoptosis of our cells rather than growth stimulation, which may also stimulate cancer cells.
Most modern epidemiology has a lot or results with ratios of 1.0 to 2.0
The most well established criteria for risk significance is the Braxton-Hicks
Criteria. Ideally to propose causality from epidemiology the ratio has to be greater than 2.0, preferably much much greater. If I remember for smoking and lung cancer the ratio is 9.0.
Personally, I disregard all ratios below 2.0 as insignificant.
Critics of nutritional epidemiology suggest that it is worthless and should be abandoned, as 80-100% of the studies fail to replicate when randomized controlled studies are done.
It's not the fat in milk that promotes PCa, nor is it IG-1 growth factor, it's the protein α-casein that proliferates LNCaP and PC3 cells. The solution is to drink goat milk with has a less harmful form of caesin-- beta-caesin.
PC3 cells treated with 1 mg/mL of α-casein and casein showed increased proliferation (228% and 166%, respectively), and the proliferation of LNCaP cells was also enhanced by 134% and 142%, respectively. The proliferation mechanism of α-casein in PC3 and LNCaP cells did not appear to be related to the induction of Insulin-like growth factor-1 (IGF-1), since the level of IGF-1 did not change upon the supplementation of casein.
The cool thing about Almond Milk is that it never seems to go bad or sour. The taste is like milk, not offensive. Lower cholesterol. Lower calories, Lower fat. We started before diagnosis20 months ago, but now also use it for coffee (High Ph Wheatgrass-delicious Bio-Coffee) smoothies. Perfect mid day snack
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