Abiraterone+PARP inhibitor better than abiraterone alone for mCRPC

[Tall_Allen]

The combo was very effective in one trial (but not in the other trial), even among those with no DNA-repair defects (like BRCA). The trials used different PARP inhibitors and the patients were different.

prostatecancer.news/2022/06...

PARP inhibitors are very toxic to some patients.

Discuss with your oncologist.

[Proflac]

Thanks for this. Were the tests for genetic defects germline or somatic?

[Tall_Allen in reply to Proflac]

Foundation One blood test, so both.

[Seasid]

My MO wanted to put me on this.

Thanks for the information. Very useful.