Choline Increases Risk of Lethal Prostate Cancer (2012)

[NecessarilySo]

This study is ten years old and may be outdated. But I tend to regard it as significant in my anti-cancer diet.

ncbi.nlm.nih.gov/pmc/articl...

"Men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer"

"Conclusion: Of the 47,896 men in our study population, choline intake was associated with an increased risk of lethal prostate cancer."

[timotur]

This was a very good study in that they attempted to adjust for various levels of choline intake stratified among different risk levels of PCa. One thing that stood out is the following paragraph between post-diagnostic and pre-diagnostic choline intake, which seems to make sense, the longer one has elevated choline intake, the greater the chance of association with lethal PCa. One thing this study implies-- stay out of the upper fifth quartile of choline consumption-- that group has 2x the number of lethal events than the lowest quartile.

We observed 271 lethal events during 33,679 person-years. Postdiagnostic choline intake was not statistically significantly associated with risk of lethal prostate cancer (HR: 1.69; 95% CI: 0.93, 3.09; P-trend = 0.20) (Table 5), and this relation was unchanged when we included red meat, milk, poultry, whole eggs, or fish in the multivariate model. However, the association became stronger after adjustment for prediagnostic intake of choline. Men in the fifth quintile of postdiagnostic choline had a risk of lethal prostate cancer nearly 2-fold that of men in the lowest quintile (HR: 1.98; 95% CI: 1.06, 3.70; P-trend = 0.08).

[London441 in reply to timotur]

My pre diagnostic intake of several things should have killed me long ago, all of which have zero nutritional value.

[NecessarilySo]

God bless eggs, but before Moses, men lived a lot longer.

[pjoshea13]

I figured the link would be to Erin - the egg lady.

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-Patrick