Xtandi timing

[john205]

I have had an excellent response to Xtandi for around 18 months but I have recently experienced intense fatigue, especially in the evening. I usually take it at around 7 AM so the problem is most intense 12-14 hours later. I guess it may not be the Xtandi, and I do not want to stop it or lower the dose, but there is nothing else going on. Any thoughts about timing for the daily dose that may be less troublesome?

[Magnus1964]

Do you take xtandi with food?

[john205 in reply to Magnus1964]

Usually

[Magnus1964 in reply to john205]

As I recall taking xtandi with food is easier on the side effects.

[john205 in reply to Magnus1964]

Thanks Magnus

[Fightinghard in reply to Magnus1964]

My MO said food or no food should not matter. But I prefer a snack before bed so I have another excuse to eat cookies

[john205 in reply to Fightinghard]

Who needs an excuse to eat cookies?

[raoulmaher]

Hi John I’m on full strength xtandi and was advised from great John to take before bed and aside from hot flushes it works for me - hope that helps kindest Raoul

[john205 in reply to raoulmaher]

Thanks

[Lychee00]

Hi John been on full dose Xtandt take at evening before bed. I had fatigue the next afternoon and I found relief the past two month by increasing hydration.

[john205 in reply to Lychee00]

Thanks Lychee

[Shooter1]

9 PM dose. No problems to speak of since cutting to 80 mg. Best of luck;

[john205 in reply to Shooter1]

Thanks

[lcfcpolo]

I take my full dose appx. 6pm with food. Sometimes struggle to wake in morning but am ok before bedtime.

[john205 in reply to lcfcpolo]

Thanks

[RyderLake2]

Hello, I have been on Xtandi (enzalutamide) for four years and six months. To overcome fatigue, take it at night. You sleep better and wake up refreshed!

[john205 in reply to RyderLake2]

Thanks

[londoncyclist48]

Yup, I take mine before bed. Probably better to take it a couple of hours before bed as others have said but I seem to have got into a bad habit of taking it immediately before bed. Almost certainly due to the fact that I am still working.

[john205 in reply to londoncyclist48]

Thanks london

[larry_dammit]

I’ve been on it now for 64 months. I found out early that I had to take it after supper to beat the side effects. Just saying. Keep up the battle warrior 🙏🙏

[john205 in reply to larry_dammit]

Thanks Larry

[SteveTheJ]

I can also suggest Provigil, a medication I've been on for a few months. It helps with fatigue and alertness. Mention it to your oncologist.

[john205 in reply to SteveTheJ]

good to know

[Wahoo_]

I take mine before bedtime….no real SE’s.

[john205 in reply to Wahoo_]

Thanks

[catsup]

take it at bedtime. works fine for me.

[john205 in reply to catsup]

Thanks

[Wahoo_ in reply to john205]

No problem….keep on keeping on brother!

[Fightinghard]

Take it 2 hours before bedtime. Works for me.

If I take it right at bedtime I seem to get heatburn

[john205 in reply to Fightinghard]

Good to know

[Parscore]

So, does anyone take Zytiga before bedtime? I do take mine with food but in the morning. Interesting discussion. Thanks.

[anonymoose2]

Eliguard +10 months 160mg 10 months 80mg all at 9 pm. Currently on med vacation. It is what it is no matter when you take it IMO. All I know it was a miracle drug for me. But every day the horrific hot flashes, fatigue that is debilitating, memory pretty close to Alzheimer’s. That’s my experience. Just 2 months in on vacation and just starting to come out of the fog. Light at end of tunnel. Starting to smell the roses. Keep fighting!!

[john205]

Will do!

[j-o-h-n]

john 2:05 I think you're tired cause you set your alarm clock too early....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 04/14/2022 7:44 PM DST

[Livingthelife]

I find It's best to take ALL cancer meds at night.