Today, I had blood work done. The PSA increase pattern is very similar to the last break. Only thing testosterone is much lower this time compared to last break. Can I read anything from this?
First Break Second Break
PSA Testosterone PSA Testosterone
3 month 0.07 <20 0.104 <20
6 month 0.135 114 0.188 28
9 month 0.453 147 0.504 72
Yes, you can see that testosterone recovery will take longer the longer you have used ADT.
Does the same increase in PSA at a lower testosterone has any significance for hormone sensitivity of cancer cells?
It's still very low. Think of castration resistance as a slow process. There will always be more cells that are resistant. Eventually, your PSA will increase in spite of ADT and you will want to add additional systemic therapies.
PARP inhibitor Olaparib, phase 3 study findings (PROpel)
MRI prior to HDR Brachy and HDR intensity.
