I was d/x with stage 4 PCA in March 2020, Gleason 7 (4+3) with lymph node Mets and a PSA of 172 (see profile). After one month of Casodex I started on Lupron and Erleada (Apalutamide) and had a PSMA/PET scan followed by 6 x 6 GY radiation to my prostate in Dec. 2020. For the past year my PSA has been undetectable (<0.008). My most recent PSA (Feb. 2022) increased to 0.025 and my ALP has also risen but still well within normal range. Does this mean I am no longer hormone sensitive? Is this considered BSR? What would be my next course of action? My MO in Toronto has left the country and I am not comfortable with the remaining choices at the hospital I am currently going to. Can anyone recommend an MO that specializes in prostate cancer in the Toronto area?
What next?: I was d/x with stage 4 PCA... - Advanced Prostate...
What next?
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Was your pelvic LN area irradiatiated when they did your prostate? Are you still taking Lupron+Erleada? Your PSA is quite low and is nothing to be concerned about.
I read that you are at Princess Margret -Excellent hospital . When you MO left did they not assign another to you? My husband is at the Odette centre at Sunnybrook and this too is an excellent cancer centre. SOC and beyond for both hospitals.
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My husband is being treated at Sunnybrook Odette as well. Very caring people there.
My most recent PSA (Feb. 2022) increased to 0.025 and my ALP has also risen but still well within normal range. Does this mean I am no longer hormone sensitive?
No, I think it means you need to stop getting ultrasensitive PSA tests. A PSA of .025 does not mean anything and there is no conclusion you could draw from it. Just have to keep a eye on it and try not to stress about the PSA (Permanent State of Anxiety)
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Thanks cancerbgone. I’m not stressed but I do like to be prepared. I will know more after my next PSA test.
First, why only one month on casodex? That's not enough time to see if it is working. Second, PSA scores in your range are not significant. Small rises of less than .5 could be due to irritations in the prostate bed. Third, you are not castrate resistant until you have failed more than one ADT drug.
IMHO The Dr. planned on treating with Lupron/Eligard only.Casodex is given for 2 weeks to a month prior to the first Lupron injection to avoid the testosterone flair that can otherwise occur with the first dose of Lupron.
You need to find new MO.Insurance generally allows you to seek 2nd opinions.
Do a little research to judge the best choices, in your budget, location, etc..
You should be able to learn far more about YOUR disease and what SOC care is best for you.
Reform a team of physicians you feel comfy with and move on.
2Dee
Dr. Urban Emmenegger. The best.
He is my husband’s MO . He lovesHim
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Great. He seems like the perfect MO.