Zytiga with breakfast?

[Rodeoz15]

Hi everyone, please could someone guide me on whether they take a lower dose of Zytiga with breakfast? If yes, do you take a low-fat or a high-fat breakfast? I searched on the forum and found posts where people were following either type of breakfast regime and a google search points towards the low fat regime.

My father is stuck up on not wanting to take the full dose so I have to look for other options (although I understand absorption might remain similar even on a low dose with food).

Many thanks!

[Tall_Allen]

Your father is mistaken if he believes that a lower dose with food will lessen side effects. As you rightly said, the absorption is the same, so the only benefit of the lower dose with food is to save money (but absorption is uncertain).

low fat: ascopubs.org/doi/10.1200/JC...

much better absorption with high fat meal: accp1.onlinelibrary.wiley.c...

Uncertain absorption: ncbi.nlm.nih.gov/labs/pmc/a...

[Rodeoz15 in reply to Tall_Allen]

Thanks, TA! The links are very helpful.

[strummer]

my husband is on low-dose zytiga. 250 mg with a low fat breakfast.-300 cal. he varies with oatmeal, poached egg, and toast, fruit. you need to eat at the same time every day and wait a few hours to eat again. He has had a good response to zytiga with minimal side effects. Univ of Colorado Uro Cancer Center approves of this method.

[Lettuce231]

I have been taking 500 mg of Zytiga for two and a half years and 5 mg of prednisone. I did it do help reduce the long term side effects, in all I've been on Zytiga for three years.

I take it with a fried egg on toast, a yoghurt and plenty of coffee, the P.S.A. came down to as low as 0.03 at one point.

There is a lot of conjecture about absorption rates, evidence for it and also against. It's your Dads decision, but he could try it and see, if it's not working go back to what he was doing before.

For me personally it's worked very well and my Oncologist has been really amazed at the success.

Good luck.

Phil

[Chrisbaird]

I’m very much the same as dosage lettuce 231. For last year has work well take 500gm zytiga an hour before I eat breakfast then cereal and toast with prednisone 5 gm PSA have remained low

[dhccpa]

Can we define a low fat meal vs a high fat meal? How many grams of fat mark the cut-off point?

And is anyone taking Zytiga with a high fat meal?

[strummer in reply to dhccpa]

our onc didn't say the amount of fat but approx 300 cal of low-fat food- yogurt, oatmeal, poached egg, toast. my husband is on 250 mg zytiga.

[dhccpa in reply to strummer]

Thanks

[DenDoc]

Interesting. I have been on Zytiga for about 10 months after Enzalutamide failed. I was prescribed 1000mg daily taken on an empty stomach 1 hour before meals. It has never upset my stomach.

[Leader4077]

I take 2 tablets of 500 mg each at 6 am and have breakfast 2 hours later with my 5 mg. Of Prednisone.

Mike B