Zytiga + Lynparza

[Stumpgirl]

Does anyone have experience on this treatment ? This is what is being suggested for my dad until possibly Lu 177.

[Tall_Allen]

Is he BRCA+?

[Stumpgirl]

apparently no but now it’s approved for non brca mutations

[Concerned-wife in reply to Stumpgirl]

In case you haven’t seen this astrazeneca.com/media-centr...

[Stumpgirl]

He just failed Xtandi

[Chrisbaird]

Started Dec 20. Was on zytiga 100 gm for 3 months but had some liver toxicity problem so then down to 50gm daily both with hormone therapy PSA went down after 3 months from 20 to 0.06 last 6 months at monthly blood test I’m 0.01 so combination works for me

[Stumpgirl in reply to Chrisbaird]

Thank you for sharing . How are the side effects

[Stumpgirl in reply to Stumpgirl]

With Lynparza

[Chrisbaird in reply to Stumpgirl]

With steroid tablet added side effects mainly hot flushes at night in summer months. while high temperatures but eases in autumn period

[Chrisbaird]

Prednisone tablet.

[IdGump]

I was on Zytiga for less than 2 years and then it stopped working. Moved on to Xtandi and then chemo which worked for now.

[whwalker1]

I was on Zytiga for 2 months and my PSA went from 15 to 125.Then was on Chemo which was not effective and now am on Lynparza and my PSA has gone from 50 to 170 in 4 months but only an increase of 35 in last 2 months.I am still hoping to get into Lu-177 trial.

[ArabianNights]

My dad was on this treatment for a year with no progression before it failed. He handled it quite well with minimal side effects. He also didn't have any of the BRCA mutations.

My dad passed away in October and never really had the chance to try other treatments (things progressed so quickly at the end) so I can't really speak to alternatives.

[Stumpgirl in reply to ArabianNights]

I am very sorry for your loss