Interested in Estradiol cream. Where on the body to apply it?

[Surla]

Hi everyone,

June 2021 completed Radiation 34 sessions following RP (Nov19.2020).

PSA (2 months after RP)0.21. CT and Bone scan before RP no Met discovered.

Latest PSA Oct 28, 2021, 0.39

Awaiting Oncologist Team to meet me on 27 Dec 2021 to decide on the next treatment (hormone therapy) .

[KSK54]

I use it on inner parts of my thighs.

RP 2010,SRT in 2018 and am using this cream for the last 7 months. PSA now <0.009.

Only side effect is little boobs.

I am very happy.

[maley2711 in reply to KSK54]

this is used as alternative to Lupron,Eligard, etc? My understanding not a SOC treatment and may not be covered, and many Docs won't prescribe?

[MateoBeach]

You should probably already be on some form of ADT to drive down testosterone to “castrate” levels <20. This is done to make the radiation more effective in the process of killing treated cancer cells. Most advocate this for 18 months to 3 years. But even 6 months is helpful and possibly sufficient if the pre RT PSA was low. Lupron and similar, or Firmagon are most often used for ADT. But topical estradiol can also work. Search for PATCH trial on this. Takes a lot of estradiol patches: wearing 4 at a time. Many MOs are not on board with this as not considered SOC, even though if T is castrate it is equivalent as ADT. Also, oncology practices make profits on Lupron injections, none for prescribing estradiol. Another consideration would be to use Lupron or similar ADT and then add estradiol in much lower dose to help or eliminate major adverse side effects while helping to preserve bone mineral density. This is much easier, only one 0.10 mg/day patch changed twice weekly or an equivalent dose of estradiol topical gel. Easier sell to the MO too. A good compromise. Tamoxifen 10 mg can prevent the otherwise inevitable gynecomastia.

[Surla in reply to MateoBeach]

Thank you very much for the information, Mateo

[j-o-h-n]

I would think,,,,,on your body.....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 11/25/2021 6:53 PM EST

[Surla in reply to j-o-h-n]

Thanks for the joke John

[j-o-h-n in reply to Surla]

The only thing I like better than humor is sarcasm.....thanks...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 11/28/2021 4:03 PM EST

[monte1111 in reply to j-o-h-n]

That’s probably betterthan the gourd you’re massaging every morning.

[j-o-h-n in reply to monte1111]

Fooled you again.....That's not my gourd.....it's my German penistraphobenhuffer....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 11/28/2021 4:01 PM EST