PSARising

[Goldberg]

On lymparza PSA rising Brica2 Mets lymph nodes and bones. Looking at Keytruda next?? Any input appreciated PSA 4to15 in 3 months.

[Tall_Allen]

I think I've mentioned before that docetaxel+carboplatin usually works when a PARP inhibitor works.

Have you had IHC of a metastasis? (I know you've had genomics)

[Goldberg in reply to Tall_Allen]

IHC? of the metastasis is it tied to the g test?

[Tall_Allen in reply to Goldberg]

Yes, of the metastasis. Done by a pathologist. Ask your oncologist.

[HopingForTheBest1]

For Keytruda to be effective you typically need to be MSI and have a high tumor burden. This info comes from your genetic test when you were identified as being BRCA2.

I am also BRCA2 ; was on Lynparza for almost 2 years with PSA undectible until it ran its course. I am now participating in a trial at Weill Cornell using a triple therapy of Actinium + Keytruda + Xtandi, with Dr Tagawa. Should hopefully know shortly, after being on the trial for 12 weeks so far, if it is helping.

[tango65]

It may work is the cancer is positive for MSI-H, and/or is PD-l1 positive. Keytruda may have severe negative side effects