Received my CDx test results yesterday, was interested in any comments. At biopsy G 9/10, PSA 8.4. Testing was performed on one of the biopsy cores. N0 M1a, metastasized to 4 lymph nodes upper abdomen. 2 CyberKnife and 25 TrueBeam. Currently on ADT (Eligard) and Zytiga with PSA at 0.067.
BRCA1 K654fs*47
TMB 5 Muts/Mb
ATR NM_001184 rearrangement intron 24
BCORL1 P1681fs*20
MSH2 loss
MSH6 loss
PPP2R1A R105Q
SPEN A2251fs*102
SPOP F133V
What really stands out to me is the MSH2 and MSH6 loss, which suggests microsatellite high. That means that Keytruda is approved for you now and will probably work well. Congratulations!
Yes, absolutely TA! Every man on this forum I think should be tested for mutations and yet it seems that so many don’t know about it. Always nice to see MSI, MSH2, MSH6, high mutational burden or a POLE mutation. Glad you made Ford 33 aware!!!
Side effects seem a little sever, anyone have experience taking it?
Some guys have autoimmune reactions; most don’t.
Yes my brother is on his 5th infusion with no side effects. He feels great
Anyone know reference to FDA Keytruda approval while still responding well to ADT and Abiraterone? Everything I have found so far relates to castrate-resistant or failure for other medications.
