Companion Diagnostic (CDx) Test Results

[33Ford]

Received my CDx test results yesterday, was interested in any comments. At biopsy G 9/10, PSA 8.4. Testing was performed on one of the biopsy cores. N0 M1a, metastasized to 4 lymph nodes upper abdomen. 2 CyberKnife and 25 TrueBeam. Currently on ADT (Eligard) and Zytiga with PSA at 0.067.

BRCA1 K654fs*47

TMB 5 Muts/Mb

ATR NM_001184 rearrangement intron 24

BCORL1 P1681fs*20

MSH2 loss

MSH6 loss

PPP2R1A R105Q

SPEN A2251fs*102

SPOP F133V

[Tall_Allen]

What really stands out to me is the MSH2 and MSH6 loss, which suggests microsatellite high. That means that Keytruda is approved for you now and will probably work well. Congratulations!

[Faith1111 in reply to Tall_Allen]

Yes, absolutely TA! Every man on this forum I think should be tested for mutations and yet it seems that so many don’t know about it. Always nice to see MSI, MSH2, MSH6, high mutational burden or a POLE mutation. Glad you made Ford 33 aware!!!

[33Ford in reply to Tall_Allen]

Side effects seem a little sever, anyone have experience taking it?

[Tall_Allen in reply to 33Ford]

Some guys have autoimmune reactions; most don’t.

[Faith1111]

Yes my brother is on his 5th infusion with no side effects. He feels great

[33Ford]

Anyone know reference to FDA Keytruda approval while still responding well to ADT and Abiraterone? Everything I have found so far relates to castrate-resistant or failure for other medications.