Nubeqa mono-therapy update

[joeguy]

So I just had my PSA checked after 3 months on Nubeqa (Darolutimide) mono therapy, and things seem to be trending in the right direction. When I started Nubeqa 3 months ago, PSA was a little over 5. After 1 month PSA dropped to 1.6, then at 2 months PSA didnt move, it was stuck at 1.6. Now at the 3 month mark, PSA is at 1.07 ! So far so good. Im sure my Uro and Onc would like to see a little bit lower number, but as long as its moving in the right direction, I am thrilled with the results.

[Magnus1964]

Here's hoping for lower PSA tests. It's always great to see your PSA continue downward.

[joeguy in reply to Magnus1964]

Thank magnus

[Spyder54]

Here Here! Here’s to your continued success!Enjoy the Wins!!

Mike

[joeguy in reply to Spyder54]

Thank you spyder

[monte1111]

Hope it continues down. Took many months for Xtandi to finally get me to 0.1 psa. With Lupron of course, and chemo had brought me to about 7.0 (High was 59.9, have extensive bone mets, now stable.)

[joeguy in reply to monte1111]

Thank you .... hoping to get a nice run from the Nubeqa. How long have you been on Xtandi? I’m hoping that when Nubeqa stops being effective, I can get back on Xtandi for s while longer

[monte1111 in reply to joeguy]

I see you had a run with Xtandi already. I will have been taking Xtandi for 4 years next month. That is about a half million dollars. Is that amazing? Or what? Can you even imagine what Lu177 will cost? They better keep that dollar printer working overtime. Heard one reason IRS was slow on refunds right now was because they ran out of printer ink. What a world, what a world. Hope the Nubeqa works well for you.

[RVALuna]

Joe guy, How did you get Nubeqa as a monotherapy? Who was your doctor and what is your dose? I am on Casodex montherapy which is inching upward after 3 i/2 years and would like to try your treatment if I can get it with our ADT??. Thanks Pedro Luna

[joeguy]

If your insurance will cover it, you can do what I did and get Relugalix with the Nubeqa, and just do not take the Relugalix. The insurance companies are kinda hung up on the “standard of care” that says Nubeqa must be taken with ADT drugs

[Jmr11820]

Nice results. Cool for you! Since we both use the same urology group in Oklahoma, curious who’s primarily guiding your treatment, your uro or MO?

[joeguy in reply to Jmr11820]

My Uro is handling all the hormone based treatments. I only see the onc every 6 months, and he pretty much defers to my Uro. I assume my Onc will have a much more prominent role when it comes time for chemo or lu177

[GeorgeGlass]

Joe, wouldn't the Nubeqa only stop the independent cancer that is not being stopped by the Orgovyx? If you only use the Nubeqa, wouldn't the other non-independent/resistant cancer continue to cause some PSA rise? I'm trying to understand how the Nubeqa AR blocker alone, can block the castration sensitive cancer as well? Did you get this concept from someone, or just practicing your own theory, in the hopes of it extending Orgovyx effectiveness for a longing period of time? How is the mono-therapy going now? It's been a year since this post. I hope it's working great for ya.

George