Why chemotherapy works for everyone but didnt work for my dad?

[Perfetto-Zeynep]

Hi

My dad had 6 docetaksel chemotherapy 15 days ago.Unfortunately PSMA Pet detected 10 new lesions on bones.

Thanks for your comments

[Hidden]

Sorry to read that chemo is not working. Unfortunately there are no guarantees in life. This site is a living testimony to this.

[Perfetto-Zeynep in reply to Hidden]

Thank you so much🙏

[tango65]

Sorry it did not work. He could ask for a liquid biopsy or a direct biopsy, to study the genome of the cancer and if they get cancer cells, they could do immunohistochemically analysis. He may have neuroendocrine or small cell PC . This cancer may have some response to Jevtana and platin compounds or m mitoxantrone, etc.. The cancer may have mutations which could indicate it will have some response to Keytruda, Olaparib, Rucaparib or similar.

[Hidden in reply to tango65]

Are these therapies available in France? I believe that is where this woman's father resides...Paris to be exact.

[Perfetto-Zeynep in reply to Hidden]

We live in Turkey

[Hidden in reply to Perfetto-Zeynep]

My apologies..how's Turkey these days.

[Perfetto-Zeynep in reply to Hidden]

our health conditions are very good but clinik researches are not being done

[Prostratehelp]

I also have not had any success with the last 3 chemo’s. My PSA has been rising for the past 7 months. Went from 5 to over 220. Bone scan and CT scans show increased leisions throughout my body. I current am being treated at Florida Cancer Specialists and Research. They are referring me to specialist at Moffitt Cancer Center. Hopefully someone will have something different to try.

[Hidden in reply to Prostratehelp]

Ask about the Vision trial..big news maker this week.

[Prostratehelp in reply to Hidden]

Thanks, I will ask about it.I have been on Eligard (since 2017), been on codesex w/ Prednisone, Zytiga, Xtandi (found to be allergic to it). Had 6 infusions on Xofiga, started on docetaxel but after 8 minutes I started having major reaction to it (had the crash cart moved in and ready to revive me but steroids helped first). Had another chemo drug but can’t remember the name (it didn’t work), been on Novatrone for 5 Infusions and it hasn’t worked either. Like I mentioned earlier post, PSA has gone from 5 to over 220 in past 6 months. Latest scans shown increased Mets through my body.

Hopefully, Doctor at Moffitt has some ideas and access to additional trials.

[Avanat in reply to Prostratehelp]

For what it’s worth, my husband, Steve, sees Dr. Jad Chahoud at Moffitt and has been very happy with him. He works with a lot of clinical trials. My husband is on this site too, under the name Stevana if you want to see his profile.

[Prostratehelp in reply to Avanat]

Thanks for your reply. I will be seeing Dr. Jain at Moffitt. He is one of the several doctors involved in prostrate (including Dr. Chahoud). My current doctor (Dr. Thaper) at Florida Cancer has a relationship with most of the doctors at Moffitt and he recommended I see Dr. Jain.One thing I forgot to put in my last message was I have also had several series of radiation on my hip and lower back. It reduced the pain I was having.

[Leader4077]

Was he taking an ADT drug along with the chemo? A little unusual for chemo to no positive results. Was that the case here?

[Perfetto-Zeynep in reply to Leader4077]

We were also very surprised that the chemotherapy didn't work. he is taking eligard once a three months

[Lavender22 in reply to Perfetto-Zeynep]

My husband had a similar experience. He had 6 rounds of chemo while also taking Eligard, but at the end they saw an uptick in spinal metastasis. They have since put him on a Zytiga generic (Abiraterone). His PSA numbers have since incrementally plummeted. Apparently chemo does not work for everyone. But there maybe a next step for your father.

Best wishes to your family.

[Perfetto-Zeynep in reply to Lavender22]

thanks a lot for your helpful advices, i wish you and your husband a very happy life 🙏god bless you

[Perfetto-Zeynep]

CAR-T is not available in our country our doctor suggested us to do lutesiumThanks🙏

[Hidden in reply to Perfetto-Zeynep]

Please? How old is dad?

[Perfetto-Zeynep in reply to Hidden]

He is 73

[bud_manning]

The problem with PCa is that it uses multiple metabolic pathways to sustain itself. All known SOC treatments only slow the cancer or kill some of it. I am stage 4 mCRPC, mets to liver and pelvis. A great deal of the research I have been reading is looking at disrupting the metabolic pathways, starving the cancer, weakening it. At the same time I have been reading about off-label drugs and supplements that do that. Some of it even improves the effectiveness of chemo, like docetaxel.

ADT, Lupron and abiraterone, quit working for me. PSA went up to 69 as of 04-02-2021. I started an off-label drug and supplement regimen in March. I started docetaxel 04-18-2021. On 05-11- my PSA was 26 and the severe pain from bone mets was gone. Everything I had read about docetaxel was that it might slow cancer progression. The results I am getting seem a lot more. I have come to the conclusion after 7 years of fighting this beast that it will take everything we can throw at it to defeat it. You gotta do the research. Get your google on: disrupting cancer cell metabolism: starving cancer; off-label drugs to fight cancer (look up Care Oncology Clinic; a book, How to Starve Cancer)

Melatonin, Thymus Extracts, Wheat Grass, Antioxidants, Milk Thistle, PSK, Vitamin A, Vitamin C, and N-Acetyl Cysteine have been reported to improve docetaxel effectiveness.

[Perfetto-Zeynep in reply to bud_manning]

we are fighting cancer for a year but nothing works long term I have read janes books but there is a lot of supplements sugessted in that book and my dad would have difficulties trying to apply them.

[bud_manning in reply to Perfetto-Zeynep]

I understand about your dad. I also understand "nothing working". Medical people said from day one we can not cure cancer. I was hesitant to take anything I did not know about. Then I decided to learn. I read all the research I could find on the off-label drugs and fighting cancer. I learned they are safe and approved for human use and that they have strong anti-cancer properties and had few side effects. I read about disrupting cancer cell metabolism. I verified everything Jane was saying from at least 2 other sources. I read enough to convince me and then my oncologist there was validity to the benefit of the drugs. He prescribed metformin, mebendazole, atorvastatin, and doxycycline for me and is monitoring. The drugs do not interfere with any treatment he is doing and may even help. The supplements will be harder, not much literature. But very few people are reporting problems with them. If you do face book, find the how to starve cancer f b page. the guides and files will help you. Basically you need to do everything on Jane's metro map because prostate cancer uses everything to survive. For me the drugs and supplements were nothing compared to the oncologists torture. But the diet, giving up meat and dairy, that is the hard part. I have to keep asking myself, "Do you want to live?". End of argument. ... I do not mean to offend here, not knowing your faith, but if I may, I pray God be with you and your father, bless you and give you peace.

[Perfetto-Zeynep in reply to bud_manning]

thanks a lot for your helpful advices,🙏god bless you

[Hidden]

It doesn’t work for everyone. Nothing does . There seems No rhyme or reason sometime to as who does well or not. Pc is a fickle enemy to us all. I’m sorry your fathers tumors persist .. I know how it feels to see dad suffer . Mine had this also . Hang by his side and love him much. Take good care of yourself also ..

[Perfetto-Zeynep in reply to Hidden]

Thank you so much🙏

[Hidden in reply to Perfetto-Zeynep]

🙏

[Peterd110]

I had 3 doses of docetaxel and psa kept increasing... a little slower but still increasing

Changed to jevtana and carboplatin and psa is dropping and pain is almost all gone and mobility is so much improved.

[Perfetto-Zeynep in reply to Peterd110]

I’m so glad you're doing well 🙏 We had 6 doses and after these doses unfortunately new metastases was seen in the PET.