How Many Ductal Prostate Cancer Fighters are Here?

[TottenhamMan]

Just wondering how many of us here have been diagnosed with Ductal Prostate Cancer? I was diagnosed with Ductal Adenocarcinoma in Oct. 2020 and I’m curious as to how other Ductal brothers are faring out there.

[Hidden]

One of my 4+3 cores Epstein said had intraductal. and another core had cribriform. None of my doctors has ever said much of anything about it. Transurethral Ultrasound didn't do it for me, knocked it down a good bit, tried to fit Cinderella's shoe on without success. Now doing radiation and 6 months ADT. Hoprefully that's a better fit. I was told by a urologist that intraductal tends to stay in the prostate longer. As Nalakrats mentioned. Otherwise I have not gotten a lot of feedback from doctors, probably because they don't know. Also, I don't know the difference between ductal and intraductal. Ductal cancers have a little less success than the most common prostate cancer. But yet better than some of the others.

[DMohr011]

I too have ductal adenocarcinoma. A pissing problem led me to finally see a Urologist who did biopsy confirming Gleason 9. And google kept telling me it was BPH! So the internet was wrong about my symptoms, hopefully the internet is wrong about ductal survivorship!

It wasn't until I went for a second opinion at Mayo did anyone explain this rare cancer type. Met with the head proton Dr who was brutally honest, but in a positive way. Good to have a care team who has treated this type of cancer often and good to have a care team that were at the top of their class!

Do you know what they call the medical student that barely passed med school? -----> Doctor!

So onward we go, and glad to see there are many of us in this forum to share the past and present.

Dave

[DMohr011]

Good info Nal. Who is your Dr? Seems you are in great hands! Also looks like you are the supplement King from other posts. If you were limited to 10 supplements, what would those be? Probably been a post out there already you can link to?

[Seebs9]

Intraductal nuroendocrine GL 9 here

[TottenhamMan]

Thanks for the information Nal, you are an icon here and a shining light for the Ductal team. You give us all hope.

[Boywonder56]

Ductal hystoligy....gl9 6 cores ...mets

[DMohr011]

Appreciate the honesty and totally understand.

Turps were needed to keep me pissing as umor had givin my eurethra a bend and blockage. Non operable due to it being stuck to or grown into the rectum. No separation can be seen. Big bulge that I could feel, and easily seen from the signoid scope.

After three months of ADP, the do not feel the bulge., and that is a positive.

My first follow up scans are scheduled for next week.

[Hidden]

Nalakrats, Did you purposely pick that MO after a search or was it fate? I am looking for a MO and I am really stressing out over it. I know I want one that is really specialized in PCa but apart from looking at the research pubs and seeing what articles they put their name to, I feel like i am flying blind.

[TottenhamMan]

I looked at my initial pathology report and it was as follows:

Grade group: 4/5

Gleason score:4+4 =8

Cribriform Pattern: Absent

Intraductal Carcinoma: Absent

Periprostatic Fat Invasion: Absent

Cancer Extent: 60% of of all tissue

Pattern 4 accounts for 100% of tumor

There is abundant papillary projections with pseudostratified nuclei consistent with Ductal morphology. Immunostains confirm prosaic origin (AMACR, PSA, and NKX3 1+). Although PIN and HMK show scattered basal cell staining, given the extent of the tumor and the absence of discrete confined ducts, a diagnosis of Ductal adenocarcinoma, gleason pattern 4 is preferred.

Extensive multi focal T2 hypointense tumor with restricted diffusion. Seminal vesical insertion bilaterally as well as the periprostatic fat, invading the left neuromuscular bundle, but no muscle invasion.

MRI:

Seminal Vesicles: bilateral invasion of the of the bases of the seminal vesicles.

Neurovascular bundles: Definite left neurovascular bundle invasion at the base and apex.

Bladder neck: Normal

Membranous Urethra: Normal

Lymph Nodes: 0.9 cm enlarged lymph node along the right internal iliac vascular bundle.

Bone Marrow: Normal

Rectal Plate: Normal

As with the DMohr011 post, no one explained this to me despite me asking a number of times with the the urologist and the oncologist.

Any help with the translation, other than I have Ductal cancer, would be helpful.

[Hidden]

Thank you. I live near Philadelphia. My pathology from Fox Chase read “mixed ductal and acinar types”. Its being stubborn.

[TottenhamMan]

Thanks for the upbeat positive message. Should I blow my brains out now?

[Hidden]

You can see my history but 18 months in i have had ralp/early salvage/lupron. I had one year of undetectable that just recently ended. My pathology after ralp was “mixed ductal and acinar types” although when i sent the slides to Epsteins lab there was no mention of ductal.

[benninger]

My husband is a gleason 10 , ductal type. His report reads Prostatic Adenocarcinoma, Ductal type , gleason score 5+5=10, with foci of comedo type necrosis.

[Cooolone]

RP in 18' with post surgical pathology identified +IDC-p

[DMohr011]

Anyone done genetic testing ? I knew 8 years ago I had Lynch syndrome, inherited from moms side. I have messed up MSH2 & EPCAM genes. Always thought my cancer would be colon. Dr said I was doomed at birth, and my cancer can be traced to the Lynch genetics. So much for those books that blame poor diets or environment.

[bethdavis]

My husband had intraductal carcinoma present in 2 of the 25 cores, along with acinar in 17 of 25.

None of the doctors have seemed concerned about the intraductal component. When I have specifically asked they said it didn’t mean anything. I find this confusing.

[Hidden in reply to bethdavis]

More or less the response I got. And when I asked the pathologist on call at JH when I had my second opinion done he wasn’t particularly clear about it either. “Controversial” i think is the word he used.

[NOCanceros]

Hello your narrator is a very rich in information thanks. Georgeהעלא דיין דערציילונג איז דאַנק צו זייער רייַך אינפֿאָרמאַציע.

דזשארזש

[spw1]

My husband has intraductal, Gl 8, extensive cribriform and comodenecrosis. Mixed with adenocarcinoma. Diagnosed with bone mets in July 2020.

[Dr_WHO]

I was diagnosed with Ductal Prostate cancer in January 2016, T3N1, G4+4. My PSA was never that high (4.7 at the time of diagnoses). Had surgery (even though it was regionally metastatic), external radiation and a little over two years of Lupron and Zytiga with prednisone. Went into NED at the end of 2018.

[MateoBeach]

Wise judgement 🙏

[leach234]

I was a Gleason 8 ductal adenocarcinoma with 2mm focal margin. PSA 5.2 before surgery. PT2 on pathology. It’s been 3 years for me and I now get PSA tested every 6 months. <0.02 ng/ml so far. I read that ductal adenocarcinoma can give off less PSA than acinar adenocarcinoma and PSA may not be a good indicator of spread so I requested an MRI of my prostate bed 2 months ago on my 3 year anniversary just to confirm no spread. Nothing found. My decipher score was 0.61.

[Purple-Bike]

Two out of biopsy samples showed intraductal cancer, one with GS 4+3 the other 3+3. I have GS 4+5 in the tumor core. Doc has not commented on the IDC yet.

[DMohr011]

I came across this research article and thought I would post. It pulls together all prior ductal research and attempts to summarize. Recently dated too.

bjui-journals.onlinelibrary...

[Dsmejkal88]

Hi! Do you have a recommendation for someone near Orlando, FL?