Extreme calf and leg pain.

[Joew0021]

Hello, I have been on Xtandi about 2 months. I started having severe calf and leg pain. To the point where I can hardly walk. Presently they've taken me off the drug and it's been 5 days. Anyone else have this problem if so how long does it take to go away incredibly painful.

[tango65]

Table I has some info:

accessdata.fda.gov/drugsatf...

[patandemma]

First make sure you you don't have a deep vein thrombosis (DVT) in your leg. That's the complication that can kill you.

[BrentW]

I had referred pain in my leg while on Zytiga (which I still am). It turned out to be from a rogue metastasis in my sacrum, which was not responding to the drug and which was found using an MRI. A quick zap of radiation sorted it out.

[ChattyC]

My hubby started on xtandi about Thanksgiving time after the PSA started rising while on zytiga. Never felt well on xtandi. Within about 3 weeks he could barely walk and was dragging around on a walker and having a hard time standing up. After another month with no PSA change, we stopped the xtandi and within 2 weeks he is walking almost normally.

[Joew0021 in reply to ChattyC]

Thank you

[Don_1213]

It seems any ADT treatment can contribute to circulatory issues, and it's worth seeing a cardio specialist to see if you're experiencing peripheral artery disease..(PAD). PAD is primarily caused by restricted or blocked leg arteries and that can be at least partly caused by the lower testosterone resulting from ADT.

Just a heads up to anyone on ADT - find a cardiologist and have them do a workup on you. Something like 35% of men on ADT die from cardio issues, a much higher percentage compared to men not on ADT.

[Phoenixrising69]

Hi Joew0021 I am in exactly the same position 2 months on xtandi and have started get the pain in my legs I’ve been using THC oil helps most times but like tonight had to have oxy as well hope this helps

[Joew0021 in reply to Phoenixrising69]

Hi, I have been making RSO(THC OIL) I TOO AM TAKING PAIN MEDS . ITS BEEN A WEEK I HAVE BEEN OFF THIS AND IS JUST STARTING TO feel a little better.

[j-o-h-n]

Greetings Joseph, Can you tell us more about yourself (so we can help)?

Please tell us your bio. Age? Location? When diagnosed? Treatment(s)? Treatment center(s)? Scores Psa/Gleason? Medications? Doctor's name(s)?

All info is voluntary, but it helps us help you and helps us too. When you respond, copy and paste it in your home page for your use and for other members’ reference.

THANK YOU AND KEEP POSTING!!!

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 03/30/2021 6:29 PM DST

[j-o-h-n]

Greetings Joseph, can you tell us more about yourself?

Please tell us your bio. Age? Location? When diagnosed? Treatment(s)? Treatment center(s)? Scores Psa/Gleason? Medications? Doctor's name(s)?

All info is voluntary, but it helps us help you and helps us too. When you respond, copy and paste it in your home page for your use and for other members’ reference.

THANK YOU AND KEEP POSTING!!!

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 03/31/2021 7:15 AM DST

[Jack02]

My dad is on xtandi and can barely walk some days he is like a cripple, they have reduced his mg to half and still no difference, shooting pains from feet to calf to shin, they are now referring him for a mri due to meta in his spine, adt therapy as such awful side effects hope you get it sorted I really do, as I know how it’s effected my par on a daily basis xx

[Jack02]

I keep asking my par this very question and he can not tell, how do you tell any suggestions? Xx

[Jack02]

My par as wide spread mets though out his skeleton, and in his spine,it does get worse at night time for sure, but doesn’t keep him awake at night, the only thing that wakes him is if he turns over and that’s his back, he takes pain meds,.... tramodol slow release morning and night, and normal tramodol 50mg in the day 2 3 times daily, if he does not have it or on time then he knows he is due, but he still as pain, some days he is great and walks good, others he can barley walk at all, mo as halved his xandi but to no benefit at all, so we have decided that he is going to go on full dose again when next sees his drug specialist in 2 wks time he is having a mri scan Thursday on his spine to see if anything is going on or his mets have got worse, thank you so much for getting back to me it means a lot hope your well xx

[Jack02 in reply to Jack02]

Ps par feels very good in his self xx

[Jack02]

Yes we can we can get them from health care shops and online do you recommend? Xx