Dexamethasone and Enzalutamide

[Hillwalker87]

Hi everyone! Dad is currently undergoing radiotherapy on his lower spine due to compression. They have also prescribed him dexamethasone. I have read there is a moderate interaction meaning that it decreases effectiveness of the Enzalutamide. Does anyone know of this and should it be of concern? Thanks as always

[Tall_Allen]

Dexamethasone has prostate cancer fighting property on its own. It is sometimes given temporarily to lower inflammatory pain from spine radiation.

[Hillwalker87 in reply to Tall_Allen]

Thanks TA. Yes they did confirm it was a temporary measure, I was probably jumping the gun asking the question to be honest.

[j-o-h-n in reply to Hillwalker87]

That's what we like.....("being honest")....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 02/27/2021 7:33 PM EST

[Hillwalker87 in reply to j-o-h-n]

🤣

[GP24]

Dexamethasone is not required with Enzalutamide. However, in the AFFIRM and PREVAIL trials, which let to the approval of Enzalutamide, the patients were allowed to use Dexamethasone if required for clinical needs. If your Dad is treated for spinal compression, Dexamethasone is more important than an unproven decrease in effectiveness of Enzalutamide.

[Hillwalker87 in reply to GP24]

I understand what you mean, many thanks for your response, much appreciated

[Hidden]

No, you shouldn't be concerned.

[Hillwalker87 in reply to Hidden]

Brill, thanks