Castrate resistant - new spot?

[SC19]

Hello wonderful people. I can't tell you how much support you have given me and my dad over the past year - if I could hug you all I could.

We are back in another quandary which I'm hoping you can shed some light on...

My dad is on Zoladex, he had had radiotherapy to the prostate and 4 x Docetaxel to treat his aPC last year. It should have been 6 x Docetaxel but it was cut short due to the Covid scare. With this, his PSA dropped to 1.1 (originally 44) in October, but January's PSA test bumped up to 7.2. He had a UTI which we think skewed this result but this led to more scans. Latest scans show prostate shrunk, 3 old mets disappeared but one new spot appeared. I wonder what you make of this - does this mean he is now castrate resistant? Did he not have enough chemo to allow a new spot to form?

Dr is now talking about Enzalutamide and/or radiotherapy again (presume to the bone spot?).

Your advice is always so much appreciated.

Thank you.

[Tall_Allen]

Yes, he is becoming castration-resistant. Xofigo, Zytiga, Xtandi, Taxotere, Jevtana, and Provenge are all good choices.

[SC19 in reply to Tall_Allen]

Thanks Tall_Allen. Would he be able to have chemo again even though he has already had 4 cycles of Docetaxel?

[Tall_Allen in reply to SC19]

Yes- chemo had great results and he never beecame resistant to it.