Docetaxel not working

[Peterd110]

I have had 2 docetaxel infusions so far with 3rd infusion scheduled this Thursday. Psa has increased from 120 to 174 and alk phos has increased from 590 to 617 since last infusion. Should I even go for 3rd infusion since docetaxel seems to be ineffective ?

[Leader4077]

Seems like your medical team should help you answer this question. I hope to hear what they say to you.I’m about to start in a Clinical trial in Seattle at SCCA/UW with Taxotere this week like you and would like to follow your progress.

Mike

[Peterd110 in reply to Leader4077]

I’ve already put in a call to the office. We’ll see what they say. Don’t see the point in continuing if it doesn’t work

What kind of trial are you going on?

[Leader4077 in reply to Peterd110]

Well it turned out the Docetaxel trial with Opdivo was going to take an additional 7-8 weeks to start for me. I chose to start the chemo Docetaxel same day and stay on Firmagon while adding prednisone . Two days later feeling fine. Did an arm IV , no port. Also going to get a new doc from SCCA at a closer satellite office in Issaquah. Hope this helps......trials are slowed down according to docs because of COVID.Mike

[Peterd110 in reply to Leader4077]

After 3 doses of docetaxel, my psa continued to rise, so now I’m going g to start jevtana and I also was able to talk the doctor into adding cisplatin to it since I’m BRCA2 positive

[Tall_Allen]

Maybe talk to them about switching to Jevtana+carboplatin

[Peterd110 in reply to Tall_Allen]

I’m brca2. Is there any data suggesting optimal sequencing with parp inhibitors?

[Tall_Allen in reply to Peterd110]

I haven't seen any sequencing trials per se for PARP inhibitors. For various cancers, if carboplatin is useful, then PARP inhibitors are often useful too - and vice versa. They seem to be complementary therapies, without cross resistance.

ncbi.nlm.nih.gov/pmc/articl...

annalsofoncology.org/articl...

sciencedirect.com/science/a...

sciencedirect.com/science/a...

[Tubbo in reply to Peterd110]

Tall_Allen is correct. I am Brca2, docetaxel didn't work for me so my doctor switched me to the platinum based chemos....carbotaxel

[Peterd110 in reply to Tubbo]

Are you on carboplatin too?

[Tubbo in reply to Peterd110]

Yes