Advanced Prostate Cancer

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Docetaxel not working

I have had 2 docetaxel infusions so far with 3rd infusion scheduled this Thursday. Psa has increased from 120 to 174 and alk phos has increased from 590 to 617 since last infusion. Should I even go for 3rd infusion since docetaxel seems to be ineffective ?

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Seems like your medical team should help you answer this question. I hope to hear what they say to you.I’m about to start in a Clinical trial in Seattle at SCCA/UW with Taxotere this week like you and would like to follow your progress.

Mike

I’ve already put in a call to the office. We’ll see what they say. Don’t see the point in continuing if it doesn’t work

What kind of trial are you going on?

Well it turned out the Docetaxel trial with Opdivo was going to take an additional 7-8 weeks to start for me. I chose to start the chemo Docetaxel same day and stay on Firmagon while adding prednisone . Two days later feeling fine. Did an arm IV , no port. Also going to get a new doc from SCCA at a closer satellite office in Issaquah. Hope this helps......trials are slowed down according to docs because of COVID.Mike

After 3 doses of docetaxel, my psa continued to rise, so now I’m going g to start jevtana and I also was able to talk the doctor into adding cisplatin to it since I’m BRCA2 positive

Maybe talk to them about switching to Jevtana+carboplatin

I’m brca2. Is there any data suggesting optimal sequencing with parp inhibitors?

I haven't seen any sequencing trials per se for PARP inhibitors. For various cancers, if carboplatin is useful, then PARP inhibitors are often useful too - and vice versa. They seem to be complementary therapies, without cross resistance.

ncbi.nlm.nih.gov/pmc/articl...

annalsofoncology.org/articl...

sciencedirect.com/science/a...