i have been on this trial for about 5 months with few side affects up until a week age but now have Peripheral Nephropathy in both feet and hands. .Oncologists had me do an MRI and now say it is not as a result of my bone Mets, or the Drugs .I am not so sure, and wonder if anybody has experience with this condition ?
i am 13 years into this Pca with no symptoms ,that is until i started getting side affects for Zytiga (18 months ),but mainly only a little fatigue .Now on the above combo i have more fatigue that is manageable but the numb feet and hands is not .
This site is great and many knowledgeable contributors unselfishly giving their time .Most valuable to us all
Xtandi+Keytruda may still work after Xtandi alone fails
To Xtandi or not to Xtandi?
Peripheral neuropathy is a side effect of several Pca drugs. I have neuropathy but not from xtandi. I have a list of drugs I take for neuropathy.
1. Mirapex 1 tablet 0.25mg - prescription
2. Gabapentin 2 capsules (300mg) - prescription
3. Acetyl L-Carnitine 1 capsule 500mg - over the counter
4. Leg Cramps (by Hylands) 2 tablets over the counter
5. Aleve PM 2 220mg - over the counter. Because Aleve can cause liver damage with long term use I have substituted Zyflamend 1 capsule.
6. CBD oil 2 drops
I take each of these drugs at least 20 minutes apart in the early evening. This helps me get a good nights sleep. The effects last all day long.
Thanks for your reply .Are you able to tell me lf the Nuropathy stops after taking of the offending drud stops or is it a permanent condition ? I have been trying large doses of B12 once a week(1000mg) but with only minimal effect .I will start on your suggestions .Thanks again
Unfortunately it is a permanent condition.
My Super Poly neuropathy Dx’d in 2009ish was from nerve damage do to my Excessive Alcohol drinking for many many years. Like 35 years. Two things help or are helping my Neuropathies feet and hands.
1. Super Vitamin B12 complex twice a day.
2. Exercising twice daily especially moving my feet Stair climbing, Eliptical, treadmill incline.
Yes. I’m continuing on B-complex since restart of my Lupron Depot 12 days ago.
Thanks for your reply.I am gong to step up my B12 intake to see how it helps .
I’ve stopped drinking Feb 2011!!! Three months later I had a Sudden Cardiac Arrest. It was primarily due to lack of Potassium and Magnesium and a bunch of other minerals feeding my heart muscles. Yeh I was also on ADHT LUPRON and Casodex bicalutimide from 2008-2012. It to probably had something to due with my SCA . I trying and pushing myself exercising twice daily. Good for the heart bad for the PCa. Will see 12 days on 2nd start of Lupron injection.