Prolia and Celebrex

[cigafred]

Tall Allen has occasionally noted, for example, that “A bone preserving agent (Zometa or Xgeva) coupled with Celebrex is probably a good idea too.” I believe Prolia and Xgeva are the same generic drug, and I am about to start Prolia, so I assume the same reasoning about Celebrex applies?

[Tall_Allen]

Maybe. Both denosumab and zoledronic acid block osteoclasts, but by different mechanisms. The RCT was only done with Zometa+Celebrex. Celebrex is a NSAID and is non-toxic for most people, so worth a try.

[cigafred]

Merci and Gratzie

[tango65]

There are not data showing a benefit by adding celebrex to denosumab (prolia or xgeva). Celebrex is not free of side effects:

"Cardiovascular Risk

• CELEBREX may cause an increased risk of serious cardiovascular thrombotic

events, myocardial infarction, and stroke, which can be fatal. All NSAIDs may

have a similar risk. This risk may increase with duration of use. Patients with

cardiovascular disease or risk factors for cardiovascular disease may be at greater

risk (see WARNINGS and CLINICAL STUDIES).

• CELEBREX is contraindicated for the treatment of peri-operative pain in the setting

of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Gastrointestinal Risk

• NSAIDs, including CELEBREX, cause an increased risk of serious gastrointestinal

adverse events including bleeding, ulceration, and perforation of the stomach or

intestines, which can be fatal. These events can occur at any time during use and

without warning symptoms. Elderly patients are at greater risk for serious

gastrointestinal events (see WARNINGS)"

accessdata.fda.gov/drugsatf...

[cigafred in reply to tango65]

Danke Schon and m goi sai (TKU)

[tango65 in reply to cigafred]

Varsågod

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“If I stay there will be trouble “

[EdBar]

I’ve been using Celebrex for about 3 years now, it was prescribed by my MO to help with the side effects of ADT - headaches, body aches etc. I cleared it with my cardiologist, she said in her 17 years of practice she’s never seen anyone have a cardiac event related to it and felt QOL is important. I haven’t had any stomach upset from it, I take it after meals. If you take Zinc supplements avoid taking them together Zinc blocks the absorption of Celebrex.

Ed

[MateoBeach]

Celebrex is considerably safer than aspirin and safer than non COX-2 NSAIDS such as ibuprofen and naproxen for CV risk. I take it daily 400 mg to complement my Prolia.

[PhilipSZacarias in reply to MateoBeach]

Naproxen is a “non- selective” COX inhibitor according to Wikipedia. Cheers, Phil

[cigafred]

Motshakeram متشکرم and thanks, Phil and Mateo and Ed.