CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

[fmenninger]

advances.sciencemag.org/con...

[fmenninger]

The targeting strategy we designed, using the ASSET linker system (22, 23), is, to our knowledge, the first example of targeted CRISPR-Cas9 therapeutic gene editing for treating metastatic tumors. It provides a highly flexible and efficient strategy for targeted gene editing that could be used by changing the antibody, for targeting either tumor cells via tumor-specific cell surface receptors (such as EpCAM or PSMA) or shared tumor and normal cell receptors (such as CD19 on B cell lymphomas), or for targeting nontransformed cells in diseased tissues.

[6357axbz]

What Nal said.

I did gather it’s talking about mice. Long way to go

[fmenninger]

sciencedaily.com/releases/2...

[fmenninger]

aacr.org/blog/2020/10/22/wh...