ADT or Orchiectomy & side effects

[lookout4]

I have been on ADT for 18 months the Side effects are a little better but still horrible!!

Q) If i have a Orchiectomy, can I stop the ADT therapy altogether? Currently on Xtandi and Orgovox.

thanks

[GP24]

You could stop the Orgovyx but you will have to continue with Xtandi. It will not make a difference regarding side effects. Orchiectomy causes about the same side effects as Orgovyx. Both lower the testosterone level which is the reason for the side effects.

[lookout4 in reply to GP24]

Thanks GP24, after I posted this, I found some additional answers, here.

I did search 8 months ago too.

We're all in this together, weather we want to admit it or not. Hang in there.

[OldGuysRule]

I’ve been asking the same question. I’ve been on Lupron and Zytiga for about 19 months. I hate it. From what I’ve learned, if I have an Orchiectomy I could drop Lupron but would still have to take Zytiga to handle testosterone created by the adrenaline glands. You guys out there correct me if I’m wrong. (I’m sure they will).

Here’s the thing, I’m a lifer so long term Lupron sounds pretty scary. If I can eliminate THAT big ole nasty med being injected in my butt, thats awesome.

The less the better!

[lookout4 in reply to OldGuysRule]

Thanks OldGuysRule , after I posted this, I found some additional answers, here.

I did search 8 months ago too.

I don't know about Lupron, I haven't had the joy..

[raoulmaher]

Hi - I am led to believe that testosterone is produced by the gonads (by the Leydig cells in testes in men ), although small quantities are also produced by the adrenal glands It is an androgen, and that it stimulates the development of male characteristics. so just removing the testes will not remove all the testosterone production !!!!! - I am on full-strength Xtandi and subcutaneous gosalin so I feel your pain so to speak - I hope this helps kindest Raoul

[jbskiatook]

I am 81 and had been on Lupron over 10 years before becoming castrate resistant. I have been on Xtandi for about 2.5 years and had a Orchiectomy around the time I went on Xtandi. I just did not like the Lupron shots and with the Orchiectomy I did not need the Lupron. I also had a pumpable penile implant for 2 reasons. One I could have sex but more important was that I would not have penile atrophy. So my Urologist said I no longer needed the dreaded Lupron shot. That shot was just painful.

[Tommyj2 in reply to jbskiatook]

Did you ever have the lupron shot administered by other practitioners? I understand there is a technique to it that makes it pretty easy…..I’ve had both lupron and eligard and neither were more than mildly uncomfortable……

[jbskiatook in reply to Tommyj2]

Yes I have had these shots under about 8 urologist and most cases thier PA. The 6 month shot was unbearable but the 3 month shot just hurt. I am not a wimp but most injuries and surgeries are one time deals and not expected to be repeated.

[Tommyj2 in reply to jbskiatook]

Sorry to hear that….guess one can only chalk it up to different skin sensitivities?

[jbskiatook in reply to Tommyj2]

Muscle is deeper than skin where the shot is until absorbed. Butt shot more painful than shoulder shot.

[Tommyj2 in reply to jbskiatook]

Eligard is given subcutaneous…that’s why I prefer it to lupron…..Agree that butt shots hurt more than shoulder.

[Vangogh1961]

Had the orch about 18 months in. I see no reason to inject a chemical for the rest of my life which a simple surgery resolved. I still take Abiraterone. I feel my hot flashes have become almost non-existent, but that may also be the time since I started treatment.

[swwags in reply to Vangogh1961]

same here and the reason we take Abiraterone is to block the production of testosterone from the Adrenal gland. The gland produces about 10 percent of a mans testosterone which is still significant risk imo.

[j-o-h-n]

Family jewels will become Family Christmas decorations.......

Good luck, Good Health and Good Health.

j-o-h-n

[Nfler in reply to j-o-h-n]

😂

[Pharm1125]

Hi,

I’ve been on doublet therapy for my nodal prostate cancer. I had a prostatectomy on 3/23. My doctor put me on Firmagon/ Xtandi about 6 months ago. I’m to continue doublet therapy for 2 years. I completed radiation therapy 11/23.

My experience with Xtandi/ Firmagon is feeling fatigue, some muscle pain, hot flashes, and occasional muscle twitches. I think that my body is getting used to the drugs bc side effects seem to be diminishing. However, I’m 6 months in on taking these drugs, so a relative newbie.

Sincerely,

JS

[Nfler]

Hi lookout I was in the same boat, could not stand the adt n just knew it was not right for me w all the hot flashes, depressed lifestyle not to mention the heavy risks to the heart which is really what made me realize I’m not going this route. So after 7 mos of reading a lot of clinical articles, I got off ADT n started ivermectin w cbd oil. My psa has dropped consistently for over a year now 1.95 down to.65. Doubling time is such a crucial marker on whether one becomes castrate resistant, and I’m going the opposite direction as my psa has more than halved, matter of fact it’s 1/3 what it was when I started ivermectin. I figure I can always get on the latest therapies down the road but thus far it looks like what I’m doing is actually killing the cancer not just suppressing it. This is my MO’s thoughts as well as he stated whatever you’re doing keep doing as it’s def working…

So hopefully n more than likely I won’t need any other therapy. Furthermore they’re using testosterone to reverse castrate resistance n in new cases kill pca as well. Good luck on whichever route you choose but I hope my results stated help…😊😇

[Tinkudi in reply to Nfler]

Can you give details of how you take the ivermectin with cbd. What dose etc ?

[Nfler in reply to Tinkudi]

Well if your trying to shrink a tumor and or kill cancer cells, I was taking 19 mg/ day four days a week. Now that it’s stabilized I do 12 mg/ day on Mon n Thur, cbd 100 mg daily along w turmeric 1900 mg daily. Vit c and or strong multivitamin daily. I’m also taking resveratrol, copper 2 mg,/5 days week along w tongkat Ali to raise my testosterone. One can also add in fen ben n sour sop as well to fight psa, hope this helps n good luck…

[Mascouche in reply to Nfler]

You were taking zinc as well, I think. Did you stop the zinc?

[Nfler in reply to Mascouche]

Well I stopped taking it by itself as it was in the multivitamin, so in essence yes I’m taking zinc as well

[Nfler in reply to Tinkudi]

pub med article

Here’s the article pic that I found so compelling n convinced me to do it

[Nfler in reply to Tinkudi]

And had great results w ivermectin only. You’ll have to look it up but shouldn’t b hard to find

Here’s a great research paper on how people in third world countries can’t afford soc.