Grandads PSA has dropped down to 0.48 after treatment of 13 cycles of docetaxel, lueprorelin shot and is currently taking daily bicalutamide.
Although everyone seems to be happy in the family about the PSA dropping I would of liked it to come down to nadir!!! Is this of concern ...
Wait...PSA might go further down....my Nadir PSA (0.2) came at 12 months from first lupron inj.
In fact, longer it takes to reach Nadir, longer the person lives. Its called TTN (time to Nadir)
I reached my Nadir after 4 years. Don't fret, it's a long journey.
Iam at 21 months and down from 350 to 13....the longer time to get there the better as studies indicate
Nadir means lowest. So 0.48 is his nadir. Great response!
With my Lupron Depot 22.5mg/12 weeks X 2 my PSA went from 20.4 to 0.03 and my T went down to <0.2 nmol/L or <5.7636887608069 ng/dL.
But my RO told me not to take 0.03 as my Nadir because that value is du to Lupron. I should wait at LEAST 6 months to a couple of years before I get to my REAL NADIR.
Nadir is not going to happen overnight - and the 'rock bottom' number will take time to get there - there are several factors to consider. Depending on the treatment(s), he may get to undetectable or he could stay at very low levels of PSA for a sustained period of time.
In MY case, I started (PSA) above 300, but that number was due to inflammation that was solved by a TURP and ADT and radiation treatment.
It was about 1 1/2 years before I hit bottom (which turned out to be undetectable).
Don't lose sleep over this - the net result isn't necessarily the end of the battle vs. the enemy.
Wishing you well on your journey .....
It took me a Gleason eight, 78 years old currently, five years to reach nadir 0.06 (2017)And I stayed there for about one year.I was being treated with Lupron only.
I was asked to comment on my husband's experience with docetaxel. His nadir with this treatment was nowhere near your grandfather's (13.25) and occurred after 11 infusions (every 3 weeks). He continued to receive 11 more infusions as the PSA slowly rose before being switched to cabazitaxel. Just after reaching that nadir the atrial valve calcium blockage was discovered when he collapsed on his way to his office. Six excruciatingly long weeks later the valve replacement surgery was done (in the nick of time, the doctor admitted). My husband had to retire as chemo brain and fatigue made him a different man from the one with whom I'd enjoyed 50 years of marriage. My husband is now doing well on Keytruda with undetectable PSA (for the first time) for the last 10 months. The last 11 years fighting mPCa with all the different treatments have taken their toll. He has had to become more of a recluse writing novels to pass the time, avoiding COVID-19.
So far it's Nay Dear..........Give it time.........
Good Luck, Good Health and Good Humor.
j-o-h-n Wednesday 10/07/2020 7:26 PM DST
Thanks for the docetaxel query. I see you have received some great replies. My prostate cancer journey and that of my late brother who died from PC earlier this year, did not include taking docetaxel.
However, I researched the use of this chemotherapy for my latest book "An ABC of Prostate Cancer Today - 3rd Edition". I also discuss the imminent Phase 3 trial of Docetaxel with the Starpharma dendrimer technology which in trials to date offers far superior performance. Probably 18 months away before it might be available.
PSA rising while ALP continues to drop?
Drop in PSA after SBRT
Update on ARV 110. PSA continues to drop
Expected drop in PSA after single Lupron shot.
