Alcohol & PCa risk: A Dose-Response Meta-Analysis

[pjoshea13]

New meta-analysis below [1].

"For non-aggressive PCa, by alcohol type, the risk increased linearly with liquor (RR per 14 g/day intake (alcohol content in standard drink) being 1.04 ... and non-linearly with beer .., with increased risk observed in the lower range (RR = 1.03 ... 14 g/day), with 1.05 ... at 28 g/day.

"Wine was not significantly associated with the risk of non-aggressive PCa.

"For aggressive PCa, a non-linear relationship of diverse shapes was indicated for all types of alcohol in the sensitivity analysis. Compared to non-drinking, a significant positive association was more apparent at lower dose for liquor (RR = 1.12 ... at 14 g/day; RR = 1.16 ... at 28 g/day; ... but at higher doses for wine (RR = 1.02 ... at 28 g/day, RR = 1.35 ... at 56 g/day; ...

"In contrast, decreased risks were indicated at lower doses of beer (RR = 0.85, ... at 14 g/day; RR = 0.79 ... at 28 g/day, ...).

"Total alcohol consumption was not associated with both types of PCa."

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/327...

Nutrients

. 2020 Jul 23;12(8):E2188. doi: 10.3390/nu12082188.

Alcohol Consumption and the Risk of Prostate Cancer: A Dose-Response Meta-Analysis

SungEun Hong 1 , Hayeong Khil 1 , Dong Hoon Lee 2 , NaNa Keum 1 2 , Edward L Giovannucci 2 3 4

Affiliations collapse

Affiliations

1 Department of Food Science and Biotechnology, Dongguk University, Goyang 10325, Korea.

2 Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02138, USA.

3 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02138, USA.

4 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02138, USA.

PMID: 32717903 DOI: 10.3390/nu12082188

Abstract

Alcohol is widely consumed and is known as a major risk factor for several types of cancers. Yet, it is unclear whether alcohol consumption is associated with the risk of prostate cancer (PCa) or not. We conducted linear and non-linear dose-response meta-analyses of cohort studies on alcohol consumption and PCa risk by types of alcohol (total, wine, beer, and liquor) and PCa (non-aggressive and aggressive). Pubmed and Embase were searched through April 2020 to identify relevant studies. Summary relative risk (RR) and 95% confidence interval (CI) were estimated using a random-effects model. For non-aggressive PCa, by alcohol type, the risk increased linearly with liquor (RR per 14 g/day intake (alcohol content in standard drink) being 1.04 (95% CI = 1.02-1.06, I2 = 0%, three studies) and non-linearly with beer (Pnon-linearity = 0.045, four studies), with increased risk observed in the lower range (RR = 1.03, 95% CI = 1.01-1.05; 14 g/day), with 1.05 (95% CI = 1.01-1.08) at 28 g/day. Wine was not significantly associated with the risk of non-aggressive PCa. For aggressive PCa, a non-linear relationship of diverse shapes was indicated for all types of alcohol in the sensitivity analysis. Compared to non-drinking, a significant positive association was more apparent at lower dose for liquor (RR = 1.12, 95% CI = 1.04-1.20 at 14 g/day; RR = 1.16, 95% CI = 1.03-1.31 at 28 g/day; Pnon-linearity = 0.005, three studies) but at higher doses for wine (RR = 1.02, 95% CI = 0.90-1.16 at 28 g/day, RR = 1.35, 95% CI = 1.08-1.67 at 56 g/day; Pnon-linearity = 0.01, four studies). In contrast, decreased risks were indicated at lower doses of beer (RR = 0.85, 95% CI = 0.79-0.92 at 14 g/day; RR = 0.79, 95% CI = 0.70-0.90 at 28 g/day, Pnon-linearity < 0.001, four studies). Total alcohol consumption was not associated with both types of PCa. In this study, we found heterogeneous associations between alcohol intake and PCa by types of alcohol and PCa.

[2] Full: sci-hub.tw/https://www.mdpi...

[Garp41]

Hops activates ER Alpha, regardless of what this study says.

Doug

[snoraste]

The results seem a little too scattered. Not surprising really for this kind of studies.

[Hidden]

Some studies conclude red wine is good. Some conclude it is neutral.

Here's one of the ones that concludes it is a positive:

"Conclusion: Cancer-free men who consumed alcohol had a slightly lower risk of lethal prostate cancer compared with abstainers. Among men with prostate cancer, red wine was associated with a lower risk of progression to lethal disease. These observed associations merit additional study but provide assurance that moderate alcohol consumption is safe for patients with prostate cancer."

pubmed.ncbi.nlm.nih.gov/310....

For things like this that are evenly split I try to figure out how it fits in with my goals. All else fails I simply do what I want. I like wine so drink a small glass of red a few times a week (I like white more than red but, if one is good for PCa and cardiac health I'd guess it would be red).

[6357axbz]

Bottle-a-day keeps the doctor away

🍷

[Hidden in reply to 6357axbz]

I'll drink to that!

[treedown]

I drank far too much beer pre-diagnosis and stopped cold turkey when dx'd. A little wine now but I have to be careful as it can escalate quickly. I felt at the time it was feeding my disease and had to admit it was feeding a disease in my marriage as well. As both are better now I don't miss it at all.

[Aynoy]

Yes a silver lining is the better relationships with reduced alcohol Still some but way back life much better

[KingNeptune]

I drink to make other people sound more interesting 🧐

[j-o-h-n in reply to KingNeptune]

I hear ya........

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/29/2020 7:27 PM DST

[KingNeptune]

Power on brother, just meant as humor.

[GeorgesCalvez]

Too many of these papers sound like final year undergraduate projects put through the paper mill.

Think of a question that can be attacked by literature search and a statistic package.

Set an undergraduate to work on it for a few months.

If it turns up something, then publish it with a few or more of your mates' names on it.

Yay, research results for a boost at the next staff review!