small cell carcinoma

[Redlog]

Has anyone else had their prostate cancer spread to the liver? If so what was the treatment plan?

[Tall_Allen]

With small cell, adding carboplatin can sometimes slow it down. Here's what we know so far:

prostatecancer.news/2016/12...

Misha Beltran at Dana Farber is probably the foremost expert. I suggest you get a second opinion from her.

[RalphieJr64]

If you didn't already have chemo, then that would be a first option. My Liver lesions started well after my 6 infusions of Docetaxel. I was put on a clinical trial that was working for almost two years. Lesions turned into small cysts. Now another lesion was recently found and I started a new clinical trial today. Hoping this will work like the last one did. It's a battle.

[DenDoc]

Yes, my prostate cancer morphed into a hybrid of small cell and adenocarcinoma. Mine is in the covering of the lungs called the pleura and also in my left lung. I did the Foundation One gene typing. My chemo was 2 years ago and it was Etoposide and Carboplatin. It totally stopped the small cell cancer from growing further. Though impacted, I am able to live a comfortable 22 months so far. I am on Lupron and Enzalutamide for my adenocarcinoma with PSA's less than 2. I have had PCa for 22 years.

See my profile.

[Eddy-Merckx]

I was diagnosed October 2019 at 49 years old with a PSA of 56 and mets in regional lymph nodes and liver . A biopsy on my liver revealed prostate cancer cells, but not small cell. Because the cancer spread to the liver, but not bones, made my oncologist (who is at Dana-Farber) thinks I developed a very aggressive form of cancer only six months earlier. I started Casodex followed by Lupron immediately after detection which reduced my PSA to 8.7 within a month. I then did six chemo (docetaxil) infusions starting in late-November (one every three weeks). My PSA dropped to 0.31 by the end of the sixth infusion. After finishing the chemo, bone and CT scans revealed the tumors/lesions had shrunk in half. My oncologist replaced the Casodex with Zytiga after chemo and my PSA dropped to 0.11 in mid-May. I will get blood work done in mid-August test how the cancer is responding.

There are a few things I learned throughout this journey. First, work with an oncologist, not a urologist. Second, my oncologist emphasized that the most aggressive approach early is most effective (for example, do not wait until a treatment fails to start Zytiga). Third, it is important for your overall health (mental and physical) to remain active. I lift weights, walk/hike, bike, swim, do yard work, yoga, play with my kids - things I like to do. Third, eat a heart-healthy diet - one that makes you feel good and allows your body to withstand the treatments better. Fourth, reduce unhealthy stress as much as possible (perhaps try relaxation techniques such as meditation). I wish you the best in your treatment.