Neuroendocrine vs small cell

[Blair77]

Hi,

My husband has been dx with treatment emergent small cell prostate cancer. Is this the same as neuroendocrine prostate cancer? The terms seem to be used interchangeably at times.

[Tall_Allen]

Small cell prostate cancer is the most prevalent kind of neuroendocrine prostate cancer. There are other kinds of neuroendocrine prostate cancer (e.g., large cell) but they are rare.

[Hidden]

Here's an article on the subject.

ncbi.nlm.nih.gov/pmc/articl...

[timotur]

Blair: here is a good paper about it, some of the differences observed in one study highlighted below...

The observed prevalence of t-SCNC is substantially higher than de novo small-cell cancer of the prostate, which occurs in < 1% of cases.4 This may reflect a transdifferentiation process after androgen-ablating therapy.26 Classic de novo SCNC is an AR-null phenotype, progressing with low serum PSA levels. In contrast, in our series of t-SCNC cases, the majority of tumors had high nuclear AR expression by IHC, and median serum PSA was > 60 ng/mL. Visceral metastases are common in de novo SCNC; in the current series, only approximately one third of patients with t-SCNC histology had liver metastases. The overlap in clinical features between patients with t-SCNC and adenocarcinoma calls into question current practice guidelines recommending metastatic biopsy to evaluate for small-cell differentiation only in cases with aggressive phenotypic features.

ncbi.nlm.nih.gov/pmc/articl...

[Hidden]

Hi. My husband was diagnosed with small cell cancer prostate, when a tumor growing on his spine was biopsies 3 weeks ago. It is an overwhelming diagnosis. He has been fighting prostate cancer since 2003 and winning, until this. We are going to Dana Farber next week to see Dr. H. Beltran, a researcher in neuroendocrine p.c. Feel free to message me. It would be nice to communicate with another wife, along on this ride. Rosie

[HanswoodRJ in reply to Hidden]

Hi Rosie.

I have large cell NEPC and am in New Zealand. My onco is not very informative and I have to keep asking for more info. Any info you could share after your meeting would be very much appreciated by us NE blokes and partners.

I am half way through the Prof Costello Cabergoline and Zinc protocol so hope it has some impact too.

Best of luck with your meeting and future treatment options.

Thanks

Ross

[AlanLawrenson in reply to HanswoodRJ]

Please tell us more about Prof Costello's protocol. Is he Melbourne based?

[dasyluo in reply to Hidden]

Hi My name is David, I am newly diagnosed with SCPC while fighting my Advanced PC sine a year ago, I am looking for some suggestions, can i please text you with some questions

[Blair77 in reply to dasyluo]

Sure, you can message me through the forum

[dasyluo in reply to Blair77]

Hi Blair, are you able to offer some advice on my situation?

[softwaremom00 in reply to Hidden]

My better half has neuroendocrine prostate cancer too. I am always up for chatting about it. Try to be hopeful. There are new treatments coming out often.

Hugs and prayers,

Softwaremom

[Neuroendo]

Yes, I think it is the same thing or very close to the same thing.